{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:42:44Z","timestamp":1769604164602,"version":"3.49.0"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,5]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>We present a case of an 88-year-old man with high-grade chondrosarcoma of the larynx. The patient presents with a history worsening dysphonia and dyspnoea treated with antibiotic and corticosteroid therapy as it was a bronchopneumonia. Thanks to fibrolaryngoscopy, radiological imaging and final biopsy with immunohistochemistry, we have done differential diagnosis with the others sarcomas of the larynx. The histological diagnosis and the correct grading are essential for treatment and management of the pathology. The best treatment is primary surgical resection with negative margins. Chemoradiotherapy may provide some benefit if there are margin positive resections or with palliative intent. In our case, we performed only surgery treatment and a close follow-up at 1-3-6 months and after every 6\u2009months. After 18\u2009months from surgery, there are no signs of recurrence of disease.<\/jats:p>","DOI":"10.1136\/bcr-2019-230918","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:10:24Z","timestamp":1568668224000},"page":"e230918","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["High-grade chondrosarcoma of the larynx: treatment and management"],"prefix":"10.1136","volume":"12","author":[{"given":"Bruno","family":"Galletti","sequence":"first","affiliation":[{"name":"Department of Adult and Development Age Human Pathology \u201cGaetano Barresi\u201d, Unit of Otorhinolaryngology, Universita degli Studi di Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Adult and Development Age Human Pathology \u201cGaetano Barresi\u201d, Unit of Otorhinolaryngology, 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