{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:12:17Z","timestamp":1789726337969,"version":"4.0.1"},"reference-count":7,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,21]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Apixaban (Eliquis) is a direct acting oral anticoagulant (DOAC) indicated for treatment of deep vein thrombosis, non-valvular atrial fibrillation, pulmonary embolism and postoperative venous thromboprophylaxis following hip or knee replacement. Complications are minimal and include, but are not limited to, bleeding and intracranial haemorrhage, and haematoma formation. Our patient is a 73-year-old woman who presented with clinical and radiographic findings of small bowel obstruction. She was found to be taking apixaban for atrial fibrillation. CT scan showed small bowel intussusception. She underwent an exploratory laparotomy and resection of the small bowel intussusception with primary side-to-side anastomosis. Histopathological examination showed that the intussusception was caused by an intramural haematoma. This case presents a rare instance of adult intussusception caused by a DOAC. To our knowledge, no case of intussusception caused by apixaban has yet been found in literature.<\/jats:p>","DOI":"10.1136\/bcr-2019-230952","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T12:40:42Z","timestamp":1572007242000},"page":"e230952","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Apixaban-induced haematoma causing small bowel intussusception"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-5293","authenticated-orcid":false,"given":"Ariel P","family":"Santos","sequence":"first","affiliation":[{"name":"Surgery, Texas Tech University, Lubbock, TX, USA"},{"name":"Department of Surgery, Covenant Medical Center\u201419th Street Campus, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Southlake Regional Health Centre, Newmarket, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Berry","sequence":"additional","affiliation":[{"name":"Surgery, Texas Tech University, Lubbock, TX, USA"},{"name":"Department of Surgery, Covenant Medical Center\u201419th Street Campus, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"2025082703513976000_12.10.e230952.1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.amjcard.2017.07.092","article-title":"Comparison of the effectiveness and safety of apixaban, dabigatran, rivaroxaban, and warfarin in newly diagnosed atrial fibrillation","volume":"120","author":"Hernandez","year":"2017","journal-title":"Am J Cardiol"},{"key":"2025082703513976000_12.10.e230952.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196361","article-title":"Benefit, risk and cost of new oral anticoagulants and warfarin in atrial fibrillation; a multicriteria decision analysis","volume":"13","author":"Mendoza-Sanchez","year":"2018","journal-title":"PLoS One"},{"key":"2025082703513976000_12.10.e230952.3","unstructured":"Soybel DI , Santos AP . Ileus and Bowel Obstruction. In: Mulholland M , Lillemoe KD , Doherty G , eds. Greenfield's surgery: scientific principles and practice. 6th edn. Philadelphia: Wolters Kluwer, 2017: 795\u20136."},{"key":"2025082703513976000_12.10.e230952.4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i26.3641"},{"key":"2025082703513976000_12.10.e230952.5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1177\/000313480707301104","article-title":"Approach to management of intussusception in adults: a new paradigm in the computed tomography era","volume":"73","author":"Rea","year":"2007","journal-title":"Am Surg"},{"issue":"Suppl","key":"2025082703513976000_12.10.e230952.6","doi-asserted-by":"crossref","DOI":"10.4174\/jkss.2009.77.Suppl.S13","article-title":"Intramural and intraluminal hematoma of the small bowel as the lead point of intussusception in an adult patient with Warfarinization","volume":"77","author":"Kwak","year":"2009","journal-title":"J Korean Surg Soc"},{"key":"2025082703513976000_12.10.e230952.7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MEJ.0b013e3282703633","article-title":"Intestinal obstruction due to spontaneous intramural hematoma of the small intestine during warfarin use: a report of two cases","volume":"14","author":"Uzun","year":"2007","journal-title":"Eur J Emerg Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:51:51Z","timestamp":1756291911000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":7,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,25]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-230952"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230952","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}