{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T01:10:01Z","timestamp":1756343401008,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,27]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>A follow-up blood count was performed on a 74-year-old woman diagnosed with colitis due to cytomegalovirus and under treatment with valganciclovir. The automated complete blood count revealed an abnormal white blood cells (WBC) scattergram together with WBC alert flags. The peripheral blood smear showed neutrophils with markedly hyposegmented nuclei or bilobed nuclei and very condensed chromatin or clumping chromatin all consistent with Pelger-Hu\u00ebt anomaly (PHA). We checked previous blood counts, ruling out an inherited PHA. We assessed the haematological, infectious and iatrogenic aetiologies for an acquired PHA. Once the valganciclovir treatment was completed and the drug was withdrawn, without changing the rest of the treatment, the morphological abnormalities of neutrophils were completely resolved. We conclude therefore that the acquired PHA presented by our patient is probably related to valganciclovir treatment.<\/jats:p>","DOI":"10.1136\/bcr-2019-230958","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T05:39:06Z","timestamp":1571031546000},"page":"e230958","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Acquired Pelger-Hu\u00ebt anomaly in a patient treated with valganciclovir"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-1485","authenticated-orcid":false,"given":"Elva","family":"Nieto-Borrajo","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Bermejo-Rodriguez","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"2025082623225099000_12.10.e230958.1","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2016-02-698506","article-title":"Abnormal chromatin clumping in myeloblasts","volume":"127","author":"Skeith","year":"2016","journal-title":"Blood"},{"key":"2025082623225099000_12.10.e230958.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21320"},{"key":"2025082623225099000_12.10.e230958.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12185-010-0625-6","article-title":"Pseudo-Pelger-Hu\u00ebt anomaly induced by transplant medications","volume":"92","author":"Wang","year":"2010","journal-title":"Int J Hematol"},{"key":"2025082623225099000_12.10.e230958.4","first-page":"48","article-title":"Reference intervals for a complete blood count on an automated haematology analyser Sysmex XN in healthy adults from the southern metropolitan area of Barcelona","volume":"29","author":"Arbiol-Roca","year":"2018","journal-title":"EJIFCC"},{"key":"2025082623225099000_12.10.e230958.5","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP3G8MDUXYSCID"},{"key":"2025082623225099000_12.10.e230958.6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ijlh.12423","article-title":"Abnormal neutrophil scattergram obtained using Pentra MS CRP in the patients with myelodysplastic syndrome showing dysgranulopoiesis","volume":"38","author":"Inaba","year":"2016","journal-title":"Int J Lab Hematol"},{"key":"2025082623225099000_12.10.e230958.7","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPVFY95MAOBKRS"},{"key":"2025082623225099000_12.10.e230958.8","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPVFY95MAOBKRS"},{"key":"2025082623225099000_12.10.e230958.9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/01.TP.0000164139.91018.EE","article-title":"Neutrophil dysplasia (acquired pseudo-Pelger anomaly) caused by ganciclovir","volume":"80","author":"Taegtmeyer","year":"2005","journal-title":"Transplantation"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:22:59Z","timestamp":1756275779000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,13]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-230958"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230958","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}