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Plasma insulin was below 0.5 mU\/L, C-peptide level was 250 pmol\/L, insulin-like growth factor (IGF)-II was 804 ng\/mL, and pro-IGF-IIE level was 80 \u00b5g\/L. Based on the clinical findings, the patient was diagnosed with non-islet cell tumour hypoglycaemia (NICTH) with an overproduction of pro-IGF-IIE and eventually IGF-II due to progressive metastatic well-differentiated gastric NET. NICTH is a very rare condition. It has been reported in several tumour types but has never been described as a consequence of NET.<\/jats:p>","DOI":"10.1136\/bcr-2019-231069","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:07:22Z","timestamp":1568668042000},"page":"e231069","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Non-islet cell tumour hypoglycaemia in a patient with a well-differentiated gastric neuroendocrine tumour"],"prefix":"10.1136","volume":"12","author":[{"given":"Judith","family":"Versluis","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlof","family":"Valk","sequence":"additional","affiliation":[{"name":"Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The 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