{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:03Z","timestamp":1756307403092,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,26]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>A 44-year-old asthmatic male patient presented to the health centre with a 3-week history of coryzal symptoms, persistent productive sputum and shortness of breath. The chest X-ray (CXR) revealed symmetrical, perihilar airspace shadowed with peribronchial cuffing and bilateral reticular markings. The patient did not improve despite treatment, and hence a high resolution CT (HRCT) scan of the thorax was recommended. The HRCT showed smooth interlobular septal thickening, central perihilar soft tissue thickening and patches of ground glass changes. Both the CXR and HRCT findings, along with the symptoms and eosinophilia counts, were suggestive of idiopathic acute eosinophilic pneumonia (IAEP) which was confirmed on bronchoalveolar lavage. The patient was successfully treated with steroids. This case highlights the symptoms, diagnosis, management and treatment of IAEP. A rapid diagnosis of this rare disease is essential since it can be completely cured with correct management but can be fatal if left untreated. Once properly treated, this disease does not recur.<\/jats:p>","DOI":"10.1136\/bcr-2019-231095","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T13:37:30Z","timestamp":1569505050000},"page":"e231095","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Idiopathic acute eosinophilic pneumonia"],"prefix":"10.1136","volume":"12","author":[{"given":"Matthew","family":"Pizzuto","sequence":"first","affiliation":[{"name":"Department of Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Seychell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Caruana Montaldo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Mizzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"2025082707561131000_12.9.e231095.1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2013.74.2.51"},{"key":"2025082707561131000_12.9.e231095.2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1164\/ajrccm\/139.1.249","article-title":"Acute eosinophilic pneumonia: a hypersensitivity phenomenon?","volume":"139","author":"Badesch","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2025082707561131000_12.9.e231095.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.5.1462"},{"key":"2025082707561131000_12.9.e231095.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.277"},{"key":"2025082707561131000_12.9.e231095.5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/20009666.2018.1466601","article-title":"Acute eosinophilic pneumonia associated with smoking: a case report","volume":"8","author":"Fayyaz","year":"2018","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"2025082707561131000_12.9.e231095.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112056"},{"key":"2025082707561131000_12.9.e231095.7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chest.2017.03.001","article-title":"Acute Eosinophilic Pneumonia: Correlation of Clinical Characteristics With Underlying Cause","volume":"152","author":"De Giacomi","year":"2017","journal-title":"Chest"},{"key":"2025082707561131000_12.9.e231095.8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/resp.12342","article-title":"Clinical implications of initial peripheral eosinophilia in acute eosinophilic pneumonia","volume":"19","author":"Jhun","year":"2014","journal-title":"Respirology"},{"key":"2025082707561131000_12.9.e231095.9","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.rmed.2014.09.011","article-title":"Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia","volume":"108","author":"Jhun","year":"2014","journal-title":"Respir Med"},{"key":"2025082707561131000_12.9.e231095.10","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199611000-00004"},{"key":"2025082707561131000_12.9.e231095.11","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819cc502"},{"key":"2025082707561131000_12.9.e231095.12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1148\/radiology.203.3.9169693","article-title":"Acute eosinophilic pneumonia: radiologic and clinical features","volume":"203","author":"King","year":"1997","journal-title":"Radiology"},{"key":"2025082707561131000_12.9.e231095.13","first-page":"325","article-title":"Reconsideration of discrepancies between clinical and histopathological features in acute eosinophilic pneumonia","volume":"31","author":"Mochimaru","year":"2015","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2025082707561131000_12.9.e231095.14","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00se01773"},{"key":"2025082707561131000_12.9.e231095.15","doi-asserted-by":"publisher","DOI":"10.1148\/rg.273065051"},{"key":"2025082707561131000_12.9.e231095.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00221811"},{"key":"2025082707561131000_12.9.e231095.17","doi-asserted-by":"crossref","unstructured":"Natarajan A , Shah P , Mirrakhimov AE , et al . 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