{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:10:01Z","timestamp":1756375801449,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,13]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Acute intermittent porphyria (AIP) is a rare condition, a metabolic disorder of the haem biosynthesis. An acute crisis of AIP can present as a combination of symptoms, such as abdominal pain, autonomic dysfunction, hyponatremia, muscle weakness and neurological symptoms in the absence of others obvious causes. We report the case of a 53-year-old woman, who was previously diagnosed with AIP 5 weeks after therapeutic suspension has developed an acute disease exacerbation. During hospitalisation, further exacerbation has occurred after analgesia with metamizole. Glucose and hemin infusions resulted in slow improvement. Physical rehabilitation was crucial to peripheral polyneuropathy recovery. Taking into account the porphyrinogenic effect described for metamizole, this drug might have triggered the second attack. Clinical history was sufficient to suspect the diagnosis and to start the treatment immediately, preventing important sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2019-231133","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T19:05:16Z","timestamp":1569870316000},"page":"e231133","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Acute intermittent porphyria: analgesia can be dangerous"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-5591","authenticated-orcid":false,"given":"Carlos Dias","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-152X","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"Mateus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Teles","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Vaio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"2025082802382156000_12.9.e231133.1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1080\/03007995.2018.1435521","article-title":"Acute intermittent porphyria: general aspects with focus on pain","volume":"34","author":"Cardenas","year":"2018","journal-title":"Curr Med Res Opin"},{"key":"2025082802382156000_12.9.e231133.2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/bjh.14459","article-title":"Update review of the acute porphyrias","volume":"176","author":"Stein","year":"2017","journal-title":"Br J Haematol"},{"key":"2025082802382156000_12.9.e231133.3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2147\/TACG.S48605","article-title":"An update of clinical management of acute intermittent porphyria","volume":"8","author":"Pischik","year":"2015","journal-title":"Appl Clin Genet"},{"key":"2025082802382156000_12.9.e231133.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.03.011"},{"key":"2025082802382156000_12.9.e231133.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.0306-5251.2007.02955.x"},{"key":"2025082802382156000_12.9.e231133.6","unstructured":"Lutz M . 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