{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:48:09Z","timestamp":1770904089363,"version":"3.50.1"},"reference-count":36,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,3]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. The left eye was within normal limits. A clinical diagnosis of choroidal melanocytoma with ocular melanocytosis was made. Enucleation OD followed by orbital implant was performed. Histopathology showed features of diffuse ocular melanocytosis involving limbus, iris, ciliary body, choroid, sclera, optic nerve head, optic nerve sheath, along with choroidal melanocytoma with extrascleral tumour extension. We presume that choroidal melanocytoma may have arisen from ocular melanocytosis.<\/jats:p>","DOI":"10.1136\/bcr-2019-231376","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T10:25:27Z","timestamp":1572431127000},"page":"e231376","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Congenital choroidal melanocytoma in a child with ocular melanocytosis"],"prefix":"10.1136","volume":"12","author":[{"given":"Arpita","family":"Maniar","sequence":"first","affiliation":[{"name":"Ocular Oncology, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumya","family":"Jakati","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-9961","authenticated-orcid":false,"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[{"name":"Ocular Oncology, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2025082623594768000_12.10.e231376.1","first-page":"11","article-title":"Melanocytes, melanocytic nevi, and MELANOCYTOMAS","volume":"4","author":"Zimmerman","year":"1965","journal-title":"Invest Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960040780019"},{"key":"2025082623594768000_12.10.e231376.3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1967.00980020333007"},{"key":"2025082623594768000_12.10.e231376.4","first-page":"638","article-title":"Malignant melanoma in melanosis oculi","volume":"71","author":"Makley","year":"1967","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"2025082623594768000_12.10.e231376.5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1967.00980020803018"},{"key":"2025082623594768000_12.10.e231376.6","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.52.12.922"},{"key":"2025082623594768000_12.10.e231376.7","first-page":"189","article-title":"Malignant melanoma of choroid in a case of nevus of Ota","volume":"11","author":"Mohandessan","year":"1979","journal-title":"Ann Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.8","first-page":"916","article-title":"Ocular melanocytosis and malignant melanoma","volume":"79","author":"Seelenfreund","year":"1979","journal-title":"NY State J. Med"},{"key":"2025082623594768000_12.10.e231376.9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000305882","article-title":"Malignant melanoma of the choroid in the nevus of Ota","volume":"159","author":"Yamamoto","year":"1969","journal-title":"Ophthalmologica"},{"key":"2025082623594768000_12.10.e231376.10","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040178010"},{"key":"2025082623594768000_12.10.e231376.11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0161-6420(82)34694-1","article-title":"Uveal malignant melanoma associated with ocular and oculodermal melanocytosis","volume":"89","author":"Gonder","year":"1982","journal-title":"Ophthalmology"},{"key":"2025082623594768000_12.10.e231376.12","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318030e81e"},{"key":"2025082623594768000_12.10.e231376.13","first-page":"1243","article-title":"Nevus fusco-caeruleus ophthalmomaxillaris","volume":"63","author":"Ota","year":"1939","journal-title":"Tokyo Med J"},{"key":"2025082623594768000_12.10.e231376.14","first-page":"119","article-title":"Ube rein in Japan sehr Haufig vorkommende nafus form, navus fusco-caeruleus ophtalmomaxillaris and ihre beziehungen zu Der augenmelanomse","volume":"45","author":"Ota","year":"1939","journal-title":"Jap J Derm Urol"},{"key":"2025082623594768000_12.10.e231376.15","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0002-9394(25)90920-8","article-title":"Melanosis oculi. A case with microscopic findings","volume":"8","author":"Reese","year":"1925","journal-title":"Am J Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.16","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0161-6420(82)34695-3","article-title":"Ocular melanocytosis. A study to determine the prevalence rate of ocular melanocytosis","volume":"89","author":"Gonder","year":"1982","journal-title":"Ophthalmology"},{"key":"2025082623594768000_12.10.e231376.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(02)01052-2"},{"key":"2025082623594768000_12.10.e231376.18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/IIO.0b013e31819248d7","article-title":"Ocular melanocytoma","volume":"49","author":"Esmaili","year":"2009","journal-title":"Int Ophthalmol Clin"},{"key":"2025082623594768000_12.10.e231376.19","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1002\/hed.23828","article-title":"Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: report of a case and review of the literature","volume":"37","author":"Tregnago","year":"2015","journal-title":"Head Neck"},{"key":"2025082623594768000_12.10.e231376.20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0002-9394(81)90290-7","article-title":"Orbital melanocytic hamartoma","volume":"91","author":"Char","year":"1981","journal-title":"Am J Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.21","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.143"},{"key":"2025082623594768000_12.10.e231376.22","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.7.990"},{"key":"2025082623594768000_12.10.e231376.23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0002-9394(77)90726-7","article-title":"Problems in the differential diagnosis of choroidal nevi and malignant melanomas","volume":"83","author":"M. Gass","year":"1977","journal-title":"Am J Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2176\/nmc.42.504","article-title":"Intracranial meningeal melanocytoma","volume":"42","author":"Hamasaki","year":"2002","journal-title":"Neurol Med Chir"},{"key":"2025082623594768000_12.10.e231376.25","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.6.1094"},{"key":"2025082623594768000_12.10.e231376.26","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1016\/j.wneu.2019.03.113","article-title":"Meningeal melanocytoma associated with nevus of Ota: analysis of twelve reported cases","volume":"127","author":"Kuo","year":"2019","journal-title":"World Neurosurg"},{"key":"2025082623594768000_12.10.e231376.27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/ICB.0b013e3181a91d56","article-title":"Diffuse choroidal melanocytoma simulating melanoma in a child with ocular melanocytosis","volume":"4","author":"Shields","year":"2010","journal-title":"Retin Cases Brief Rep"},{"key":"2025082623594768000_12.10.e231376.28","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/S0161-6420(86)33519-X","article-title":"Diffuse choroidal melanocytoma in a child. A lesion extending the spectrum of melanocytic hamartomas","volume":"93","author":"Haas","year":"1986","journal-title":"Ophthalmology"},{"key":"2025082623594768000_12.10.e231376.29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.sjopt.2013.06.013","article-title":"Uveal melanoma in children and teenagers","volume":"27","author":"Shields","year":"2013","journal-title":"Saudi Journal of Ophthalmology"},{"key":"2025082623594768000_12.10.e231376.30","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910515)67:10<2642::AID-CNCR2820671040>3.0.CO;2-0"},{"key":"2025082623594768000_12.10.e231376.31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00000637-199309000-00012","article-title":"Extensive malignant melanoma of the uvea in childhood: resection and immediate reconstruction with microsurgical and craniofacial techniques","volume":"31","author":"Posnick","year":"1993","journal-title":"Ann Plast Surg"},{"key":"2025082623594768000_12.10.e231376.32","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1966.03850010079015"},{"key":"2025082623594768000_12.10.e231376.33","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0008-4182(05)80055-9","article-title":"Congenital uveal malignant melanoma: a case report","volume":"40","author":"Palazzi","year":"2005","journal-title":"Canadian Journal of Ophthalmology"},{"key":"2025082623594768000_12.10.e231376.34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaapos.2013.11.020","article-title":"Congenital uveal malignant melanoma","volume":"18","author":"Pukrushpan","year":"2014","journal-title":"J Aapos"},{"key":"2025082623594768000_12.10.e231376.35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3129\/i10-118","article-title":"Congenital choroidal melanoma in an infant","volume":"46","author":"Rai","year":"2011","journal-title":"Can J Ophthalmol"},{"key":"2025082623594768000_12.10.e231376.36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.survophthal.2015.07.005","article-title":"Biscotti cv congenital uveal melanoma?","volume":"61","author":"Singh","year":"2016","journal-title":"Surv Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:59:58Z","timestamp":1756277998000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,30]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-231376"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231376","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}