{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:42:51Z","timestamp":1756384971805,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,11]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>A 64-year-old woman presented with bilateral visual loss with shimmering photopsias as the only clinical manifestation of an occult pancreatic ampullary adenocarcinoma causing duct dilatation. Abnormal electroretinograms led to suspicion of cancer-associated retinopathy (CAR), and CT of the abdomen showed an underlying pancreatic malignancy, detected with subclinical liver function tests following diagnosis of CAR. Biopsy showed a T2N0M0 ampullary adenocarcinoma. The patient was managed with Whipple\u2019s procedure and adjuvant chemotherapy and has made a good recovery with no progression of her retinopathy. To our knowledge, this is one of the first descriptions of CAR in the context of pancreatic malignancy. It is atypical in its asymmetric presentation and favourable patient outcome. CAR is an important diagnosis to make, as ocular manifestations can be the only indication of an occult malignancy, resulting in a swifter diagnosis and potentially life-saving early intervention.<\/jats:p>","DOI":"10.1136\/bcr-2019-231444","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T06:15:46Z","timestamp":1573452946000},"page":"e231444","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cancer-associated retinopathy in ampullary pancreatic cancer"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-2419","authenticated-orcid":false,"given":"Nima","family":"Ghadiri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-9801","authenticated-orcid":false,"given":"Yunfei","family":"Yang","sequence":"additional","affiliation":[{"name":"John Radcliffe Hospital, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin JL","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"},{"name":"Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,11,10]]},"reference":[{"key":"2025082712075370000_12.11.e231444.1","doi-asserted-by":"publisher","DOI":"10.1159\/000338240"},{"key":"2025082712075370000_12.11.e231444.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.104"},{"key":"2025082712075370000_12.11.e231444.3","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.3748\/wjg.v21.i26.7970","article-title":"Management of ampullary neoplasms: a tailored approach between endoscopy and surgery","volume":"21","author":"Panzeri","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2025082712075370000_12.11.e231444.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-008-0114-7"},{"key":"2025082712075370000_12.11.e231444.5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/01.iae.0000450880.26367.4e","article-title":"Autoimmune retinopathy and antiretinal antibodies","volume":"34","author":"Grewal","year":"2014","journal-title":"Retina"},{"key":"2025082712075370000_12.11.e231444.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00416-2"},{"key":"2025082712075370000_12.11.e231444.7","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1097\/IAE.0b013e3181e097f0","article-title":"Fundus autofluorescence and optical coherence tomographic findings in acute zonal occult outer retinopathy","volume":"30","author":"Fujiwara","year":"2010","journal-title":"Retina"},{"key":"2025082712075370000_12.11.e231444.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90125-2"},{"key":"2025082712075370000_12.11.e231444.9","doi-asserted-by":"crossref","unstructured":"Morita M , Fukuhara T , Takahashi H , et al . 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