{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:14:25Z","timestamp":1783358065926,"version":"3.54.6"},"reference-count":5,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,26]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. At 13 months, she remains on low calcium formula, and has gross motor delay, central hypotonia and early hand preference. Review of 102 articles yielded 119 SFNN cases. Asphyxia was reported in 78%. Twenty-one per cent had hypoglycaemia. Twenty per cent underwent therapeutic hypothermia. Median onset of skin lesions was day 6 (range: 1\u201370), with a median duration of 62 days (range: 14\u2013390). Hypercalcaemia developed in 53% (median onset day 28, range: 1\u2013210). Fifty-two per cent of hypercalcaemia was asymptomatic. Outcome information was provided in 106\/119 cases; 87% reported a full resolution. Persistent calcinosis was present in 6%. Babies treated with therapeutic hypothermia should be closely monitored for SFNN, and development of hypercalcaemia.<\/jats:p>","DOI":"10.1136\/bcr-2019-231458","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:19:36Z","timestamp":1576473576000},"page":"e231458","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Subcutaneous fat necrosis of the newborn"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-1757","authenticated-orcid":false,"given":"Niamh","family":"O' Brien","sequence":"first","affiliation":[{"name":"Neonatology, Rotunda Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breda","family":"Hayes","sequence":"additional","affiliation":[{"name":"Neonatology, Rotunda Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"2025082707281754000_12.12.e231458.1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/pde.13640","article-title":"Subcutaneous fat necrosis of the newborn and associated hypercalcemia: a systematic review of the literature","volume":"36","author":"Stefanko","year":"2019","journal-title":"Pediatr Dermatol"},{"key":"2025082707281754000_12.12.e231458.2","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1111\/apa.13463","article-title":"Macrosomia and haemodynamic instability may represent risk factors for subcutaneous fat necrosis in asphyxiated newborns treated with hypothermia","volume":"105","author":"Courteau","year":"2016","journal-title":"Acta Paediatr"},{"key":"2025082707281754000_12.12.e231458.3","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1111\/pde.12973","article-title":"Subcutaneous fat necrosis of the newborn: a 20-year retrospective study","volume":"33","author":"Del Pozzo-Maga\u00f1a","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"2025082707281754000_12.12.e231458.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07782.x"},{"key":"2025082707281754000_12.12.e231458.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3508"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:28:24Z","timestamp":1756304904000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,15]]},"published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1136\/bcr-2019-231458"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231458","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}