{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:40Z","timestamp":1787017060932,"version":"build-2736575974"},"reference-count":14,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,10]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Calcium pyrophosphate deposition (CPPD) disease is a crystal arthropathy primarily affecting peripheral joints, most commonly the wrist and the knees. However, CPPD in the cervical spine is a rare entity. This report describes a case of CPPD of the cervical spine which presents with symptoms of neck pain and brachalgia. A 62-year-old woman presented with left-sided upper limb and neck pain. MRI scanning revealed a low signal abnormality within the C6 and C7 vertebrae, and the possibility of lymphoma was raised. The patient was recalled for gadolinium-enhanced scans which showed perivertebral and marrow enhancement. Fine-needle aspirate histology initially suggested a spindle cell tumour or lymphoma. However, CT-guided biopsy showed positively birefringent crystals, confirming CPPD. CPPD of the spine is a rare differential of nerve impingement in the cervical spine when MRI scanning perivertebral signal enhancement. Furthermore, CPPD of the spine can mimic malignancy.<\/jats:p>","DOI":"10.1136\/bcr-2019-231508","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T05:43:30Z","timestamp":1575351810000},"page":"e231508","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Pseudogout or pseudolymphoma? Calcium pyrophosphate deposition disease of the cervical spine: a rare presentation and literature review"],"prefix":"10.1136","volume":"12","author":[{"given":"Sanchit","family":"Turaga","sequence":"first","affiliation":[{"name":"Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Royal Berkshire Hospital, Reading, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Savy","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"2025082623130375000_12.12.e231508.1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2217\/ijr.11.60","article-title":"Calcium pyrophosphate crystal deposition","volume":"6","author":"Sivera","year":"2011","journal-title":"Int J Clin Rheumtol"},{"key":"2025082623130375000_12.12.e231508.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.182"},{"key":"2025082623130375000_12.12.e231508.3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.rdc.2014.01.011","article-title":"Diagnosis and clinical manifestations of calcium pyrophosphate and basic calcium phosphate crystal deposition diseases","volume":"40","author":"Ea","year":"2014","journal-title":"Rheum Dis Clin North Am"},{"key":"2025082623130375000_12.12.e231508.4","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200209010-00028"},{"key":"2025082623130375000_12.12.e231508.5","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-016-0928-1","article-title":"Acute neck pain caused by pseudogout attack of calcified cervical yellow ligament: a case report","volume":"10","author":"Kobayashi","year":"2016","journal-title":"J Med Case Rep"},{"key":"2025082623130375000_12.12.e231508.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-2776-z"},{"key":"2025082623130375000_12.12.e231508.7","first-page":"256","article-title":"Calcium pyrophosphate dihydrate crystal deposition disease in cervical radiculomyelopathy","volume":"66","author":"Chen","year":"2005","journal-title":"J Chin Med Assoc"},{"key":"2025082623130375000_12.12.e231508.8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/acr.21952","article-title":"Evidence of a systemic predisposition to chondrocalcinosis and association between chondrocalcinosis and osteoarthritis at distant joints: a cross-sectional study","volume":"65","author":"Abhishek","year":"2013","journal-title":"Arthritis Care Res"},{"key":"2025082623130375000_12.12.e231508.9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3171\/jns.1980.52.2.0279","article-title":"Cervical radiculomyelopathy caused by deposition of calcium pyrophosphate dihydrate crystals in the ligamenta flava. Case report","volume":"52","author":"Kawano","year":"1980","journal-title":"J Neurosurg"},{"key":"2025082623130375000_12.12.e231508.10","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.jemermed.2015.02.005","article-title":"Crowned dens syndrome: report of three cases and a review of the literature","volume":"49","author":"Oka","year":"2015","journal-title":"J Emerg Med"},{"key":"2025082623130375000_12.12.e231508.11","first-page":"1040","article-title":"The Crowned dens syndrome as a cause of neck pain: clinical and computed tomography study in patients with calcium pyrophosphate dihydrate deposition disease","volume":"26","author":"Salaffi","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"2025082623130375000_12.12.e231508.12","first-page":"545","article-title":"The cervical spine in calcium pyrophosphate dihydrate deposition disease. A prevalent case-control study","volume":"31","author":"Finckh","year":"2004","journal-title":"J Rheumatol"},{"key":"2025082623130375000_12.12.e231508.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.05.028"},{"key":"2025082623130375000_12.12.e231508.14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1440-1673.1990.tb02815.x","article-title":"Cervical myelopathy in C.P.P.D. deposition disease","volume":"34","author":"Parker","year":"1990","journal-title":"Australas Radiol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:13:16Z","timestamp":1756275196000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,2]]},"published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1136\/bcr-2019-231508"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231508","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}