{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:07Z","timestamp":1790612047596,"version":"4.1.0"},"reference-count":21,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,12,4]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>A 63-year-old woman with a medical history of chronic myelogenous leukaemia treated with dasatinib, chronic obstructive pulmonary disease and heart failure with preserved ejection fraction presented with difficulty in breathing. Chest X-ray showed large right-sided pleural effusion, which was confirmed on a CT angiogram of the chest. Echocardiogram showed an ejection fraction of 61% with moderate to severely dilated right ventricle and right ventricular systolic pressure of 60\u2009mm Hg. Diagnostic and therapeutic thoracentesis was performed, and 2.2 L of pleural fluid was removed. Pleural fluid analysis was consistent with chylothorax. Significant symptomatic improvement was noted after thoracentesis. In the absence of an alternate explanation, chylothorax was attributed to dasatinib, which was switched to nilotinib. This resulted in resolution of her pleural effusions.<\/jats:p>","DOI":"10.1136\/bcr-2019-231653","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T04:45:17Z","timestamp":1576557917000},"page":"e231653","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Chylothorax: complication attributed to dasatinib use"],"prefix":"10.1136","volume":"12","author":[{"given":"Abdullah","family":"Al-abcha","sequence":"first","affiliation":[{"name":"Internal Medicine, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian Harris","family":"Iftikhar","sequence":"additional","affiliation":[{"name":"Sleep Medicine, Washington University, St Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi","family":"Abu Rous","sequence":"additional","affiliation":[{"name":"Internal Medicine, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Laird-Fick","sequence":"additional","affiliation":[{"name":"Internal Medicine, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"2025082700283479000_12.12.e231653.1","first-page":"71","article-title":"Dasatinib-induced chylothorax in chronic myeloid leukemia","volume":"30","author":"Baloch","year":"2017","journal-title":"Proc"},{"key":"2025082700283479000_12.12.e231653.2","doi-asserted-by":"crossref","DOI":"10.4103\/1817-1737.191871","article-title":"Dasatinib-induced pleural effusion: chylothorax, an option to consider","volume":"11","author":"Ferreiro","year":"2016","journal-title":"Ann Thorac Med"},{"key":"2025082700283479000_12.12.e231653.3","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2012.0196"},{"key":"2025082700283479000_12.12.e231653.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.08.010"},{"key":"2025082700283479000_12.12.e231653.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2009.06.008"},{"key":"2025082700283479000_12.12.e231653.6","doi-asserted-by":"crossref","unstructured":"Lindauer M , Hochhaus A . 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