{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:41:02Z","timestamp":1761864062926,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,25]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>We present a case of new-onset asthma in a 35-year-old man who had undergone bilateral lung transplantation 11 years before due to idiopathic bronchiectasis and pulmonary hypertension. He presented with recurrent episodes of breathlessness, wheezing and coughing. Spirometry demonstrated severe airway obstruction. After treatment with systemic and inhaled corticosteroids and long-acting bronchodilators as well as short-acting beta-agonists as needed, his symptoms resolved and his spirometry normalised. A bronchial mannitol challenge test showed significant airway hyperresponsiveness and is thus consistent for a diagnosis of asthma. To our best knowledge, this is the first case of late new-onset asthma in a lung transplant recipient.<\/jats:p>","DOI":"10.1136\/bcr-2019-231654","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T01:45:10Z","timestamp":1572659110000},"page":"e231654","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["New-onset asthma in a bilateral lung transplant patient"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-1743","authenticated-orcid":false,"given":"Daniel Benjamin","family":"Fyenbo","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine Bruun","family":"Degn","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Martin","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Bendstrup","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"2025082804045179000_12.11.e231654.1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90941-9"},{"key":"2025082804045179000_12.11.e231654.2","doi-asserted-by":"crossref","DOI":"10.1186\/1749-8090-6-92","article-title":"A review of bronchiolitis obliterans syndrome and therapeutic strategies","volume":"6","author":"Hayes","year":"2011","journal-title":"J Cardiothorac Surg"},{"key":"2025082804045179000_12.11.e231654.3","unstructured":"Global Initiative for Asthma . Global strategy for asthma management and prevention, 2018. Available: https:\/\/ginasthma.org\/wp-content\/uploads\/2018\/04\/wms- GINA-2018-report-V1.3-002.pdf"},{"key":"2025082804045179000_12.11.e231654.4","doi-asserted-by":"crossref","DOI":"10.1186\/1465-9921-6-144","article-title":"The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline","volume":"6","author":"Brannan","year":"2005","journal-title":"Respir Res"},{"key":"2025082804045179000_12.11.e231654.5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1586\/17476348.2013.847370","article-title":"The usefulness of the mannitol challenge test for asthma","volume":"7","author":"Porsbjerg","year":"2013","journal-title":"Expert Rev Respir Med"},{"key":"2025082804045179000_12.11.e231654.6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1097\/00000542-199012000-00030","article-title":"Airway obstruction in lungs obtained from an asthmatic donor complicating heart-lung transplantation","volume":"73","author":"Ghosh","year":"1990","journal-title":"Anesthesiology"},{"key":"2025082804045179000_12.11.e231654.7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1053-2498(03)00192-X","article-title":"Donor history of asthma is not a contraindication to lung transplantation: 12-year single-center experience","volume":"23","author":"Oto","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"2025082804045179000_12.11.e231654.8","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2013.00263","article-title":"Pathology of asthma","volume":"4","author":"Kudo","year":"2013","journal-title":"Front Microbiol"},{"key":"2025082804045179000_12.11.e231654.9","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080612"},{"key":"2025082804045179000_12.11.e231654.10","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1164\/arrd.1987.135.4.976","article-title":"Human heart-lung transplantation: physiologic aspects of the denervated lung and post-transplant obliterative bronchiolitis","volume":"135","author":"Estenne","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"2025082804045179000_12.11.e231654.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6634.1427"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:04:58Z","timestamp":1756379098000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,1]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/bcr-2019-231654"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231654","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}