{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:47:19Z","timestamp":1791910039389,"version":"4.3.4"},"reference-count":15,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,11,5]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Cytomegalovirus (CMV) infection of the gastrointestinal tract is common in immunosuppressed patients; however, small bowel perforation from tissue-invasive CMV disease after many years of immunosuppressive therapy is a rare complication requiring timely medical and surgical intervention. We report a case of a postrenal transplant patient who presented to the emergency department with severe lower abdominal pain with CT of the abdomen\/pelvis revealing a small bowel perforation. He underwent an emergent laparoscopic right hemicolectomy, and his histopathology of the terminal ileum was positive for CMV disease. He was successfully treated with intravenous ganciclovir postoperatively. We discuss the pathophysiology, histopathological features and treatment of CMV infection.<\/jats:p>","DOI":"10.1136\/bcr-2019-231662","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T04:45:20Z","timestamp":1574743520000},"page":"e231662","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-7672","authenticated-orcid":false,"given":"Kosuke","family":"Kato","sequence":"first","affiliation":[{"name":"Department of General Surgery, Gold Coast University Hospital, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Gold Coast University Hospital, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"2025082712093284000_12.11.e231662.1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i1.17"},{"key":"2025082712093284000_12.11.e231662.2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.6061\/clinics\/2015(07)09","article-title":"Cytomegalovirus infection in transplant recipients","volume":"70","author":"Azevedo","year":"2015","journal-title":"Clinics"},{"key":"2025082712093284000_12.11.e231662.3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp408"},{"key":"2025082712093284000_12.11.e231662.4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1399-3062.2011.00705.x","article-title":"Risk factors and clinical outcomes of cytomegalovirus disease occurring more than one year post solid organ transplantation","volume":"14","author":"Blyth","year":"2012","journal-title":"Transpl Infect Dis"},{"key":"2025082712093284000_12.11.e231662.5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/TP.0000000000000030","article-title":"Delayed-Onset cytomegalovirus disease coded during Hospital readmission after kidney transplantation","volume":"98","author":"Santos","year":"2014","journal-title":"Transplantation"},{"key":"2025082712093284000_12.11.e231662.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00624.x"},{"key":"2025082712093284000_12.11.e231662.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-214196","article-title":"Perforation of the bowel due to cytomegalovirus infection in a man with AIDS: surgery is not always necessary!","volume":"2016","author":"Yoganathan","year":"2016","journal-title":"BMJ Case Rep"},{"key":"2025082712093284000_12.11.e231662.8","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-6-45","article-title":"Small bowel perforation due to CMV enteritis infection in an HIV-positive patient","volume":"6","author":"Michalopoulos","year":"2013","journal-title":"BMC Res Notes"},{"key":"2025082712093284000_12.11.e231662.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02139220"},{"key":"2025082712093284000_12.11.e231662.10","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00015-13"},{"key":"2025082712093284000_12.11.e231662.11","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829df29d"},{"key":"2025082712093284000_12.11.e231662.12","doi-asserted-by":"crossref","unstructured":"Barling DR , Tucker S , Varia H , et al . Large bowel perforation secondary to CMV colitis: an unusual primary presentation of HIV infection. BMJ Case Rep 2016;2016. doi:doi:10.1136\/bcr-2016-217221. 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