{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:34:55Z","timestamp":1761514495450,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,11,19]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>A 50-year-man presented with debilitating lower-limb proximal muscle weakness and hip pain since 3 years. Investigations (serum calcium (8.9\u2009mg\/dL), serum phosphorus (1.5\u2009mg\/dL), serum albumin (40\u2009g\/L), parathyroid hormone (116\u2009pg\/mL (12.30\u2009pmol\/L)), 25(OH)D3 (25.2\u2009ng\/mL (63\u2009nmol\/L)) 1,25(OH)<jats:sub>2<\/jats:sub> D3 (19\u2009pg\/mL (45.60\u2009pmol\/L)), tubular reabsorption of phosphate of 0.22 and elevated serum fibroblast growth factor 23 (FGF23) (387.7 RU\/mL)) were consistent with tumour-induced osteomalacia (TIO). Localisation studies (<jats:sup>68<\/jats:sup>Ga DOTATATE positron emission tomography (PET)\/CT and <jats:sup>18<\/jats:sup>FDG-PET\/CT) did not reveal any lesion. Re-evaluation after 2 and 5 years with <jats:sup>68<\/jats:sup>Ga-DOTANOC PET\/CT showed 2\u00d71.4\u2009cm progressively increasing rounded soft tissue enhancing mass close to splenic hilum (SUV max: 26.4). Tumour was resected by laparotomy. Both FGF23 (120 RU\/mL on day 3) and serum phosphorus (2.5\u2009mg\/dL on day 10) normalised with significant clinical improvement after surgery. Histopathology revealed phosphaturic mesenchymal tumour. Here, we report the first case of intra-abdominal mesenchymal tumour causing TIO diagnosed by serial functional imaging.<\/jats:p>","DOI":"10.1136\/bcr-2019-231728","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T04:55:19Z","timestamp":1575521719000},"page":"e231728","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Tumour-induced osteomalacia due to an intra-abdominal mesenchymal tumour"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-9217","authenticated-orcid":false,"given":"Brijesh","family":"Krishnappa","sequence":"first","affiliation":[{"name":"Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati Ramteke","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag R","family":"Lila","sequence":"additional","affiliation":[{"name":"Endocrinology, Seth GS Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar R","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"2025082707562507000_12.12.e231728.1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060909"},{"key":"2025082707562507000_12.12.e231728.2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0006"},{"key":"2025082707562507000_12.12.e231728.3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bonr.2017.09.002","article-title":"Tumor-Induced osteomalacia","volume":"7","author":"Florenzano","year":"2017","journal-title":"Bone Rep"},{"key":"2025082707562507000_12.12.e231728.4","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160811","article-title":"Oncogenic osteomalacia: role of Ga-68 DOTANOC PET\/CT scan in identifying the culprit lesion and its management","volume":"90","author":"Singh","year":"2017","journal-title":"Br J Radiol"},{"key":"2025082707562507000_12.12.e231728.5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/cen.12426","article-title":"Functional imaging in primary tumour-induced osteomalacia: relative performance of FDG PET\/CT vs somatostatin receptor-based functional scans: a series of nine patients","volume":"81","author":"Jadhav","year":"2014","journal-title":"Clin Endocrinol"},{"key":"2025082707562507000_12.12.e231728.6","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s00198-017-4007-2","article-title":"Tumor-Induced osteomalacia: experience from a South American academic center","volume":"28","author":"Gonz\u00e1lez","year":"2017","journal-title":"Osteoporos Int"},{"key":"2025082707562507000_12.12.e231728.7","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1642"},{"key":"2025082707562507000_12.12.e231728.8","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1881"},{"key":"2025082707562507000_12.12.e231728.9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/1346-8138.12602","article-title":"Phosphaturic mesenchymal tumor, mixed connective tissue type, non-phosphaturic variant: report of a case and review of 32 cases from the Japanese published work","volume":"41","author":"Honda","year":"2014","journal-title":"J Dermatol"},{"key":"2025082707562507000_12.12.e231728.10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00774-016-0756-9","article-title":"Reports of 17 Chinese patients with tumor-induced osteomalacia","volume":"35","author":"Yu","year":"2017","journal-title":"J Bone Miner Metab"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:56:31Z","timestamp":1756306591000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,4]]},"published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1136\/bcr-2019-231728"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231728","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}