{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:42:40Z","timestamp":1760132560156,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,10]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Chikungunya viral (CHIKV) fever is often a self-limiting febrile illness associated with severe debilitating arthralgia. Neurological complications associated with CHIKV, although rare, have been reported in literature; however, longitudinally extensive transverse myelitis (LTEM) is rarely associated with it. We present a case of a middle-aged man with a 1-week history of low-grade fever and arthralgia followed by urinary retention and quadriplegia. A sensory level was noted at T2. On subsequent investigations, he was diagnosed with LETM. Although LETM is commonly seen in patients with neuromyelitis optica, the other possible etiologies are inflammatory and parainfectious. To date, only two cases of LETM are reported worldwide in association with CHIKV fever and this is the first case from Pakistan. With frequent chikungunya outbreaks, neurological complications are increasingly seen in clinical practice. The knowledge of these associations will result in their early diagnosis and treatment.<\/jats:p>","DOI":"10.1136\/bcr-2019-231745","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T08:09:11Z","timestamp":1570781351000},"page":"e231745","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Longitudinally extensive transverse myelitis with seropositive chikungunya"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-9393","authenticated-orcid":false,"given":"Sajid","family":"Hameed","sequence":"first","affiliation":[{"name":"Neurology, Aga Khan University Hospital, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubashar","family":"Memon","sequence":"additional","affiliation":[{"name":"Neurology, Aga Khan University Hospital, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"Neurology, Aga Khan University Hospital, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dureshahwar","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Neurology, Aga Khan University Hospital, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"2025082703161047000_12.10.e231745.1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1978"},{"key":"2025082703161047000_12.10.e231745.2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.injms.2016.12.003","article-title":"Longitudinally extensive transverse myelitis caused by Chikungunya virus","volume":"8","author":"Singh Jain","year":"2017","journal-title":"Indian Journal of Medical Specialities"},{"key":"2025082703161047000_12.10.e231745.3","unstructured":"Gonz\u00e1lez-Galv\u00e1n LM , Arredondo-Ruiz P , Chac-Lezama G , et al . Transverse myelitis associated to chikungunya virus infection. Med Int Mex 2017;33."},{"key":"2025082703161047000_12.10.e231745.4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/WCO.0000000000000093","article-title":"Longitudinally extensive transverse myelitis","volume":"27","author":"Tobin","year":"2014","journal-title":"Curr Opin Neurol"},{"key":"2025082703161047000_12.10.e231745.5","doi-asserted-by":"crossref","first-page":"e170538","DOI":"10.1590\/0074-02760170538","article-title":"Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases","volume":"113","author":"Vieira","year":"2018","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2025082703161047000_12.10.e231745.6","first-page":"13","article-title":"Chikungunya virus associated Guillain-Barre Syndrome with variable presentation: A case series","volume":"13","author":"Farooq","year":"2018","journal-title":"Pakistan Journal of Neurological Sciences (PJNS)"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-231745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:16:21Z","timestamp":1756289781000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-231745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":6,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,10]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-231745"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-231745","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}