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Clinical and biochemical investigations confirmed significant hyperandrogenism and insulin resistance, and a diagnosis of HAIR-AN syndrome was made after exclusion of other differential diagnoses. HAIR-AN syndrome is an important diagnosis for the adolescent gynaecologist to be aware of, and it requires a multidisciplinary approach, including endocrinology input, for optimal management. Weight loss, lifestyle modification and combined hormonal pill and metformin are considered first-line treatment.<\/jats:p>","DOI":"10.1136\/bcr-2019-231749","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T03:45:11Z","timestamp":1586490311000},"page":"e231749","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome): an extreme subphenotype of polycystic ovary syndrome"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-1966","authenticated-orcid":false,"given":"Brooke","family":"O'Brien","sequence":"first","affiliation":[{"name":"Paediatric and Adolescent Gynaecology, Department of Paediatric Surgery, Queensland Children's Hospital, South Brisbane, Queensland, Australia"},{"name":"School of Medicine, The University of Queensland, St Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Dahiya","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Queensland, St Lucia, Queensland, Australia"},{"name":"Department of Endocrinology, Queensland Children's Hospital, South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kimble","sequence":"additional","affiliation":[{"name":"Paediatric and Adolescent Gynaecology, Department of Paediatric Surgery, Queensland Children's Hospital, South Brisbane, Queensland, Australia"},{"name":"Women's and Newborn Services, Royal Brisbane and Woman's Hospital Health Service District, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"2025082711522396000_13.4.e231749.1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1100\/tsw.2004.106","article-title":"Clinical profiles, occurrence, and management of adolescent patients with HAIR-AN syndrome","volume":"4","author":"Omar","year":"2004","journal-title":"ScientificWorldJournal"},{"key":"2025082711522396000_13.4.e231749.2","article-title":"Virilising ovarian tumour in a woman with an adrenal nodule","volume":"2010","author":"Rivera-Arkoncel","year":"2010","journal-title":"Case Rep Child Meml Hosp Chic"},{"key":"2025082711522396000_13.4.e231749.3","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1016\/j.jpag.2011.12.016","article-title":"Polycystic ovary syndrome mimicking an androgen-secreting tumor","volume":"25","author":"Veilleux-Lemieux","year":"2012","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"2025082711522396000_13.4.e231749.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"2025082711522396000_13.4.e231749.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1430"},{"key":"2025082711522396000_13.4.e231749.6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ecl.2016.01.004","article-title":"Polycystic ovary syndrome in adolescents","volume":"45","author":"Witchel","year":"2016","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025082711522396000_13.4.e231749.7","unstructured":"Rothenberg S , Beverley R , Barnard E , et al . 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