{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:08Z","timestamp":1756374008661,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>We report the case of an otherwise healthy 60-year-old man presenting with fever, leucocytosis and a painful swelling of the right calf. We initially performed cultural and cytological examination of the popliteal fossa mass, but the results were disappointingly inconclusive. The subsequent development of several erythematous subcutaneous nodules, rapidly evolving to broad ulcerative lesions, prompted us to reconsider the clinical setting as a whole, which included fever, marked leucocytosis and multiple subcutaneous nodules. A biopsy of the ulcerative lesions finally led to the diagnosis of neutrophilic panniculitis, which was sustained by a hybrid myelodysplastic\/myeloproliferative disorder like BCR-ABL1-negative atypical chronic myeloid leukaemia. The patient was initially treated with high-dose intravenous corticosteroids, resulting in a dramatic improvement of the skin lesions and normalisation of blood tests. Azacytidine treatment was subsequently started, and the haematological disease remained stable.<\/jats:p>","DOI":"10.1136\/bcr-2019-232005","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T14:55:13Z","timestamp":1570546513000},"page":"e232005","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical neutrophilic panniculitis as presentation of BCR-ABL1-negative chronic myeloid leukaemia"],"prefix":"10.1136","volume":"12","author":[{"given":"Paolo","family":"Fraticelli","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Interna, Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona Umberto I G M Lancisi G Salesi, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devis","family":"Benfaremo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche Facolt\u00e0 di Medicina e Chirurgia, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cardinali","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche Facolt\u00e0 di Medicina e Chirurgia, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna, Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona Umberto I G M Lancisi G Salesi, Ancona, Italy"},{"name":"Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche Facolt\u00e0 di Medicina e Chirurgia, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"2025082802113888000_12.10.e232005.1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.clindermatol.2013.11.004","article-title":"Neutrophilic dermatoses as systemic diseases","volume":"32","author":"Prat","year":"2014","journal-title":"Clin Dermatol"},{"key":"2025082802113888000_12.10.e232005.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.12.954"},{"key":"2025082802113888000_12.10.e232005.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.06.003"},{"key":"2025082802113888000_12.10.e232005.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"2025082802113888000_12.10.e232005.5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0190-9622(83)70191-X","article-title":"Neutrophilic dermatosis of myeloproliferative disorders. atypical forms of pyoderma gangrenosum and sweet's syndrome associated with myeloproliferative disorders","volume":"9","author":"Caughman","year":"1983","journal-title":"J Am Acad Dermatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-232005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:11:48Z","timestamp":1756372308000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-232005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,8]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-232005"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-232005","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}