{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:10:20Z","timestamp":1756314620462,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,2,6]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Metastatic disease to the parotid lymph nodes typically occurs secondary to head and neck and cutaneous squamous cell carcinomas (SCC). Nasal septal SCC is an exceedingly rare primary cancer that rarely spreads to regional lymph nodes. A 39-year-old man presented with left-sided cervical lymphadenopathy and nasal polyposis. Initial assessment suggested that he may have a head and neck SCC of unknown origin with nodal deposits in close proximity to the parotid gland. Cross-sectional imaging did not reveal the primary source. After further review of imaging and examination under anaesthetic, the primary SCC was found on the left nasal septum. The patient ultimately required a type 1 craniofacial resection and adjuvant chemoradiotherapy to treat the disease. Thorough investigation of the \u2018unknown primary\u2019 SCC including cross-sectional imaging and endoscopic examination is essential for the diagnosis of rare and unusual primary SCCs. Nasal septal SCC can be successfully managed with combined modality treatment in the form of surgical resection and chemoradiotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2019-232096","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T04:25:12Z","timestamp":1582691112000},"page":"e232096","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Intraparotid lymph node metastasis from a nasal septal carcinoma: an unusual source of the unknown primary"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-4847","authenticated-orcid":false,"given":"Andrew John","family":"Williamson","sequence":"first","affiliation":[{"name":"Otolaryngology, Charing Cross Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Haywood","sequence":"additional","affiliation":[{"name":"Otolaryngology, Charing Cross Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Awad","sequence":"additional","affiliation":[{"name":"Otolaryngology, Charing Cross Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"2025082709305174000_13.2.e232096.1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1445-2197.2011.05669.x","article-title":"Nasal septum malignancy","volume":"81","author":"Ho","year":"2011","journal-title":"ANZ J Surg"},{"key":"2025082709305174000_13.2.e232096.2","article-title":"Squamous cell carcinoma of nasal septum","volume":"36","author":"Jan","year":"1986","journal-title":"J Pak Med Assoc"},{"key":"2025082709305174000_13.2.e232096.3","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-201765","article-title":"'Saddle nose' deformity caused by advanced squamous cell carcinoma of the nasal septum","volume":"2014","author":"Graham","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2025082709305174000_13.2.e232096.4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5606\/kbbihtisas.2014.77200","article-title":"Squamous cell carcinoma originating from the nasal septal perforation: a rare nasal tumor","volume":"24","author":"Cukurova","year":"2014","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"2025082709305174000_13.2.e232096.5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1079"},{"key":"2025082709305174000_13.2.e232096.6","unstructured":"American Joint Committee on Cancer . 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