{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:00:02Z","timestamp":1768453202322,"version":"3.49.0"},"reference-count":45,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,11,24]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Penile calciphylaxis is a rare but clinically challenging condition to manage. While multiple treatment options have been proposed, the underlying evidence is anecdotal, and the overall prognosis remains extremely poor. We describe the case of a patient who underwent urgent debridement of a suspected gangrenous penile tip, who was intraoperatively found to have penile calciphylaxis. The necrosis progressed and the patient had a glans amputation. A non-healing wound developed, requiring reconstruction with two skin grafts using foreskin by the plastic and reconstructive surgical unit. The patient was commenced on sodium thiosulfate and his wound had completely healed 2\u2009months following his last operation. We review the literature to determine the biochemical features, management options and outcomes in patients with penile calciphylaxis.<\/jats:p>","DOI":"10.1136\/bcr-2019-232138","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T05:05:50Z","timestamp":1575608750000},"page":"e232138","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-1204","authenticated-orcid":false,"given":"Rowan","family":"David","sequence":"first","affiliation":[{"name":"Urology Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Lee","sequence":"additional","affiliation":[{"name":"Urology Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Dean","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"2025082722491872000_12.12.e232138.1","first-page":"1","article-title":"Penile calciphylaxis in end stage renal disease","volume":"2013","author":"Barbera","year":"2013","journal-title":"Case Rep Urol"},{"key":"2025082722491872000_12.12.e232138.2","doi-asserted-by":"crossref","DOI":"10.1016\/S0090-4295(02)01713-2","article-title":"Penile calciphylaxis","volume":"60","author":"Jacobsohn","year":"2002","journal-title":"Urology"},{"key":"2025082722491872000_12.12.e232138.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-4806(09)72903-1"},{"key":"2025082722491872000_12.12.e232138.4","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181e3b0f2"},{"key":"2025082722491872000_12.12.e232138.5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1346-8138.2001.tb00082.x","article-title":"Fulminant and relentless cutaneous necrosis with excruciating pain caused by calciphylaxis developing in a patient undergoing peritoneal dialysis","volume":"28","author":"Sato","year":"2001","journal-title":"J Dermatol"},{"key":"2025082722491872000_12.12.e232138.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00311-7"},{"key":"2025082722491872000_12.12.e232138.7","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000064334.85656.a1"},{"key":"2025082722491872000_12.12.e232138.8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1515\/med-2018-0025","article-title":"Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature","volume":"13","author":"Yang","year":"2018","journal-title":"Open Medicine"},{"key":"2025082722491872000_12.12.e232138.9","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(86)90077-4"},{"key":"2025082722491872000_12.12.e232138.10","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1365-2230.2008.02999.x","article-title":"Sudden onset of calciphylaxis: painful violaceous Livedo in a patient with peritoneal dialysis","volume":"34","author":"Funabiki","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"2025082722491872000_12.12.e232138.11","doi-asserted-by":"crossref","first-page":"259-c","DOI":"10.1001\/archderm.136.2.259-c","article-title":"Penile necrosis","volume":"136","author":"Boccaletti","year":"2000","journal-title":"Arch Dermatol"},{"key":"2025082722491872000_12.12.e232138.12","doi-asserted-by":"crossref","unstructured":"Harris CF , Mydlo JH . 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