{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:45:29Z","timestamp":1793814329292,"version":"4.6.1"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,1,14]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Statin-induced necrotising autoimmune myopathy (SINAM) is a rare disease characterised by proximal muscle weakness and elevated creatine kinase levels that is usually in the thousands. Anti-3-hydroxy-3-methyl glutaryl co-enzyme A reductase (HMGCR) antibodies are associated with SINAM. Autoimmune hepatitis (AIH) is an inflammatory disease of the liver that is usually of unknown aetiology but can also be associated with concurrent extrahepatic autoimmune disorders. We are reporting a case of biopsy proven AIH associated with SINAM in a patient presenting with oropharyngeal dysphagia. The patient had elevated anti-HMGCR antibodies and anti-smooth muscle antibodies. SINAM and AIH were confirmed by muscle biopsy and liver biopsy, respectively. The patient had complete resolution of his symptoms and complete normalisation of his liver function tests after 6 months of the treatment.<\/jats:p>","DOI":"10.1136\/bcr-2019-232391","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T04:35:12Z","timestamp":1580963712000},"page":"e232391","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Statin-induced necrotising autoimmune myopathy and autoimmune hepatitis presenting with dysphagia"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-6399","authenticated-orcid":false,"given":"Osama","family":"Qasim Agha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Jospeh's Hospital and Medical Center, Phoenix, Arizona, USA"},{"name":"Department of Internal Medicine, Creighton University School of Medicine, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Jospeh's Hospital and Medical Center, Phoenix, Arizona, USA"},{"name":"Department of Internal Medicine, Creighton University School of Medicine, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-0327","authenticated-orcid":false,"given":"Nirmal","family":"Vijayavel","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"2025082710051064000_13.2.e232391.1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6447a1"},{"key":"2025082710051064000_13.2.e232391.2","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s11606-015-3303-9","article-title":"An unusual case of statin-induced myopathy: anti-HMGCoA necrotizing autoimmune myopathy","volume":"30","author":"Nichols","year":"2015","journal-title":"J Gen Intern Med"},{"key":"2025082710051064000_13.2.e232391.3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23854"},{"key":"2025082710051064000_13.2.e232391.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.04.037"},{"key":"2025082710051064000_13.2.e232391.5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00228-018-2589-z","article-title":"Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase","volume":"75","author":"Essers","year":"2019","journal-title":"Eur J Clin Pharmacol"},{"key":"2025082710051064000_13.2.e232391.6","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181c74e0d"},{"key":"2025082710051064000_13.2.e232391.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.07.001"},{"key":"2025082710051064000_13.2.e232391.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.34673"},{"key":"2025082710051064000_13.2.e232391.9","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834b324b"},{"key":"2025082710051064000_13.2.e232391.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.005"},{"key":"2025082710051064000_13.2.e232391.11","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/imj.13561","article-title":"HMG CoA reductase inhibitor associated myositis and autoimmune hepatitis","volume":"47","author":"Palamuthusingam","year":"2017","journal-title":"Intern Med J"},{"key":"2025082710051064000_13.2.e232391.12","first-page":"1","article-title":"A case of atorvastatin-associated necrotizing autoimmune myopathy, mimicking idiopathic polymyositis","volume":"2018","author":"Dixit","year":"2018","journal-title":"Case Rep Rheumatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-232391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:05:17Z","timestamp":1756314317000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-232391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,5]]},"published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1136\/bcr-2019-232391"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-232391","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}