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We present a case of an atraumatic idiopathic splenic rupture in University Hospital, Ayr in a patient who received G-CSF treatment for chemotherapy-induced (methotrexate) pancytopenia and was successfully managed by laparoscopic splenectomy.<\/jats:p>","DOI":"10.1136\/bcr-2019-232411","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T03:45:14Z","timestamp":1586490314000},"page":"e232411","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Atraumatic idiopathic splenic rupture induced by granulocyte-colony stimulating factor (G-CSF) for the treatment of pancytopenia, managed successfully by laparoscopic splenectomy"],"prefix":"10.1136","volume":"13","author":[{"given":"Ugochukwu Chinyere","family":"Chinaka","sequence":"first","affiliation":[{"name":"General Surgery, University Hospital Ayr, Ayr, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-3668","authenticated-orcid":false,"given":"Joshua","family":"Fultang","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Ayr, Ayr, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelizaveta","family":"Pereca","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Ayr, Ayr, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajid","family":"Ali","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Ayr, Ayr, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"2025082622491495000_13.4.e232411.1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12659\/AJCR.883739","article-title":"Spontaneous splenic rupture: a rare life-threatening condition; diagnosed early and managed successfully","volume":"14","author":"Weaver","year":"2013","journal-title":"Am J Case Rep"},{"key":"2025082622491495000_13.4.e232411.2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0972-9941.158950","article-title":"Laparoscopic splenectomy for spontaneous rupture of the spleen","volume":"12","author":"Thapar","year":"2016","journal-title":"J Minim Access Surg"},{"key":"2025082622491495000_13.4.e232411.3","first-page":"1","article-title":"Diagnosis and treatment of atraumatic splenic rupture: experience of 8 cases","volume":"2019","author":"Liu","year":"2019","journal-title":"Gastroenterol Res Pract"},{"key":"2025082622491495000_13.4.e232411.4","doi-asserted-by":"crossref","unstructured":"Renzulli P , Hostettler A , Schoepfer AM , et al . 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