{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:45:10Z","timestamp":1769150710016,"version":"3.49.0"},"reference-count":18,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,28]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Spontaneous hepatic rupture is an uncommon cause of haemorrhagic shock and very rarely happens due to amyloidosis. This report describes one such case in which a middle-aged man presented in extremis. He was managed initially with massive transfusion, interventional radiology embolisation and decompressive laparotomy for abdominal compartment syndrome. Subsequent coagulopathy was treated with activated factor VII due to deficient native activity. Serum protein electrophoresis and liver biopsy during his hospital course yielded a diagnosis of amyloidosis, which was treated palliatively with steroids and bortezomib. Despite supportive care, he died 10 days after presentation. This case illustrates the importance of considering an uncommon pathology when a patient presents with a condition in an uncommon way.<\/jats:p>","DOI":"10.1136\/bcr-2019-232448","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T06:51:55Z","timestamp":1572591115000},"page":"e232448","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Spontaneous hepatic rupture due to primary amyloidosis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-4937","authenticated-orcid":false,"given":"Shravan","family":"Leonard-Murali","sequence":"first","affiliation":[{"name":"Surgery, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Nasser","sequence":"additional","affiliation":[{"name":"Surgery, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Ivanics","sequence":"additional","affiliation":[{"name":"Surgery, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Woodward","sequence":"additional","affiliation":[{"name":"Surgery, Henry Ford Hospital, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"2025082801215078000_12.10.e232448.1","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-129-4-199808150-00029","article-title":"Recurrent spontaneous hepatic rupture in primary hepatic amyloidosis","volume":"129","author":"Kacem","year":"1998","journal-title":"Ann Intern Med"},{"key":"2025082801215078000_12.10.e232448.2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000189084","article-title":"Fatal spontaneous liver rupture in a renal transplant patient with amyloidosis","volume":"73","year":"1996","journal-title":"Nephron"},{"key":"2025082801215078000_12.10.e232448.3","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-222942","article-title":"Hepatic amyloidosis: a cause of rapidly progressive jaundice","volume":"22","author":"Ford","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082801215078000_12.10.e232448.4","doi-asserted-by":"publisher","DOI":"10.1024\/1023-9332.9.2.92"},{"key":"2025082801215078000_12.10.e232448.5","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1055\/s-0032-1325340","article-title":"Spontaneous Hepatic Rupture in Amyloidosis \u2013 Report of a Case","volume":"50","author":"Lehmann","year":"2012","journal-title":"Zeitschrift f\u00fcr Gastroenterologie"},{"key":"2025082801215078000_12.10.e232448.6","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-43-2-406","article-title":"Primary amyloidosis with spontaneous rupture of the spleen and sudden death","volume":"43","author":"DRAPIEWSKI","year":"1955","journal-title":"Ann Intern Med"},{"key":"2025082801215078000_12.10.e232448.7","doi-asserted-by":"crossref","DOI":"10.4254\/wjh.v8.i6.340","article-title":"Primary hepatic amyloidosis: a case report and review of literature","volume":"8","author":"Sonthalia","year":"2016","journal-title":"World J Hepatol"},{"key":"2025082801215078000_12.10.e232448.8","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.jvir.2016.08.003","article-title":"Hepatic artery embolization for hepatic rupture in HELLP syndrome","volume":"27","author":"Gutovich","year":"2016","journal-title":"J Vasc Interv Radiol"},{"key":"2025082801215078000_12.10.e232448.9","doi-asserted-by":"crossref","unstructured":"Cotta-Pereira RL , Valente LF , De Paula DG , et al . 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