{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:23:33Z","timestamp":1790709813446,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,4,28]]},"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Paediatric sinonasal tumours comprise numerous aetiologies. Ewing\u2019s sarcoma (ES) consists of a malignancy of neuroectodermal origin. This type of sarcoma affects mainly children and adolescents and can assume the skeletal or extra-skeletal form. Primary ES of head and neck is extremely rare, accounting for only 4%\u20139% of all cases. So far, as much as we know, only a few cases of sinonasal ES have been reported in literature. The authors present a case of a previous healthy 12-year-old girl who presented with a rapidly growing and expansive frontal mass and unilateral nasal obstruction. Immunohistochemical, molecular and cytogenetic analysis of the lesion showed diffuse expression of CD56 and CD99 on tumour cells and a translocation involving chromosome 22q12, confirming ES diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2019-232460","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T05:51:38Z","timestamp":1590040298000},"page":"e232460","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Extra-skeletal Ewing\u2019s sarcoma of the frontal sinus: a rare disorder in pediatric age"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-5923","authenticated-orcid":false,"given":"Isabel Esteves","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, Hospital de Braga, Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-3811","authenticated-orcid":false,"given":"Ana","family":"Sousa Menezes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, Hospital de Braga, Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-9394","authenticated-orcid":false,"given":"Antonio Fontes","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, Hospital de Braga, Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, Hospital de Braga, Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"2025082712324863000_13.5.e232460.1","article-title":"Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions","volume":"3","author":"Jedlicka","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"key":"2025082712324863000_13.5.e232460.2","unstructured":"Ginsberg JP , Woo SY , Hicks MJ , et al . 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