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Cerebrospinal fluid (CSF) opening pressure was normal on lumbar puncture and <jats:italic>Treponema pallidum<\/jats:italic> antibodies and <jats:italic>T. pallidum<\/jats:italic> particle agglutination test were positive on CSF analysis. He tested negative for HIV. Symptoms rapidly resolved with 2\u2009weeks of intravenous benzylpenicillin. At 1\u2009month follow-up, the right optic nerve swelling had reduced while the left optic nerve swelling had increased; his vision remained unaffected and he was symptom free and continued to have no objective evidence of optic nerve dysfunction.<\/jats:p>","DOI":"10.1136\/bcr-2019-232520","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T05:05:14Z","timestamp":1577077514000},"page":"e232520","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Neurosyphilis presenting as visually asymptomatic bilateral optic perineuritis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-950X","authenticated-orcid":false,"given":"Jason","family":"Yosar","sequence":"first","affiliation":[{"name":"Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"2025082722075019000_12.12.e232520.1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143304","article-title":"Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting","volume":"10","author":"Newman","year":"2015","journal-title":"PLoS One"},{"unstructured":"World Health Organization . 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