{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:32:01Z","timestamp":1762507921632,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,11,4]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Herpes simplex virus (HSV) can affect the central nervous system causing meningitis, encephalitis and, rarely, acute retinal necrosis. We present a case of a 46-year-old man, previously healthy complaining of a 5-day persistent headache and sudden loss of vision of his left eye that progressed to the right. We started ceftriaxone, methylprednisolone and acyclovir for suspected encephalitis with vasculitis. HSV-1 was identified in vitreous and aqueous humour. Therapy with acyclovir was maintained and two intravitreous boluses of foscarnet were administered, without improvement. Usually being a benign infection, HSV can, in rare cases like this, have catastrophic effects in the optic tract.<\/jats:p>","DOI":"10.1136\/bcr-2019-232566","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T05:43:53Z","timestamp":1575351833000},"page":"e232566","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Acute retinal necrosis by herpes simplex virus type 1: an unusual presentation of a primary infection"],"prefix":"10.1136","volume":"12","author":[{"given":"Gon\u00e7alo Pereira","family":"Cruz","sequence":"first","affiliation":[{"name":"Infectious Diseases, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Saraiva da Cunha","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"2025082700352278000_12.12.e232566.1","unstructured":"WHO . Fact sheets: herpes simplex v\u00edrus, 2016. 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Acute retinal necrosis: diagnosis, management, complications and outcomes of an 8 year retrospective case series. 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