{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:56:54Z","timestamp":1787169414754,"version":"build-2736575974"},"reference-count":26,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,26]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Use of medications including vitamin A derivatives and tetracyclines have been associated with papilledema and raised intracranial pressure. A 46-year-old woman was referred to neuro-ophthalmology for bilateral optic disc oedema and had a 7-year history of cyclosporine use after renal transplantation. She had preserved visual function and moderate bilateral optic disc oedema. Magnetic resonance imaging and magnetic resonance venography of the brain were normal apart from signs of raised intracranial pressure. Lumbar puncture revealed an elevated opening pressure of 40\u2009cm of water with normal cerebrospinal fluid contents. Nephrology was consulted and cyclosporine was switched to tacrolimus and she was treated with acetazolamide. The papilledema resolved within 1\u2009month of her initial visit. It is important to recognise the role that cyclosporine plays in raising intracranial pressure, especially in patients requiring immunosuppression, such as transplant patients. Tacrolimus is a suitable alternative in these cases.<\/jats:p>","DOI":"10.1136\/bcr-2019-232725","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T05:09:27Z","timestamp":1574226567000},"page":"e232725","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Resolution of papilledema associated with cyclosporine use after change to tacrolimus"],"prefix":"10.1136","volume":"12","author":[{"given":"Caberry W","family":"Yu","sequence":"first","affiliation":[{"name":"School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology of Vision Sciences, University of Toronto, Toronto, Ontario, 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