{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:32:54Z","timestamp":1762507974890,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,12,13]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Hypereosinophilic syndrome (HES) is a rare disorder characterised by eosinophilic infiltration of tissues. Myocardial infiltration occurs in 50%\u201360% of HES and leads to a condition called Loeffler\u2019s endocarditis. This can lead to endomyocardial injury with resultant superimposed thrombus formation and embolic stroke. We describe the case of a 57-year-old female patient presenting with neurological symptoms who was found to have multiple embolic strokes on a background of long-standing eosinophilia. Following a series of investigations, including transthoracic and transoesophageal echocardiographies and cardiovascular MRI, she was confirmed to have Loeffler\u2019s endocarditis with left ventricular thrombus. She was treated successfully with steroids and anticoagulation. We describe the pathophysiology of HES and Loeffler\u2019s endocarditis and stress the crucial role of multimodality cardiac imaging in establishing its diagnosis and treatment monitoring.<\/jats:p>","DOI":"10.1136\/bcr-2019-232786","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:45:14Z","timestamp":1578030314000},"page":"e232786","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["When multimodality cardiac imaging saves the day: rare cause of embolic strokes"],"prefix":"10.1136","volume":"13","author":[{"given":"Polyvios","family":"Demetriades","sequence":"first","affiliation":[{"name":"Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Speke","sequence":"additional","affiliation":[{"name":"Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowella","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal Nasir","family":"Khan","sequence":"additional","affiliation":[{"name":"Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"2025082803381976000_13.1.e232786.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"2025082803381976000_13.1.e232786.2","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","volume":"83","author":"Weller","year":"1994","journal-title":"Blood"},{"key":"2025082803381976000_13.1.e232786.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.001"},{"key":"2025082803381976000_13.1.e232786.4","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.256"},{"key":"2025082803381976000_13.1.e232786.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00288.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-232786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:38:29Z","timestamp":1756377509000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-232786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,2]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/bcr-2019-232786"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-232786","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}