{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:41:56Z","timestamp":1756384916286,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,3,23]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>A 64-year-old woman with refractory cellulitis in the lower legs was referred for inadequate glycaemic control. Physical examination revealed cushingoid features including central obesity. CT of the abdomen revealed a right adrenal mass that was positive on <jats:sup>131<\/jats:sup>I-adosterol imaging. Findings on endocrine evaluation confirmed a diagnosis of Cushing\u2019s syndrome, which was cured with a right adrenalectomy. Two months after surgery, the patient complained of pain and marked swelling of the hands during hydrocortisone replacement therapy (20\u2009mg per day) given for postoperative adrenal insufficiency. Laboratory examination was unremarkable. However, contrast-enhanced T2-weighted MRI of the hands revealed enhanced signals surrounding the flexor tendons, leading to a diagnosis of remitting seronegative symmetrical synovitis with pitting oedema. Prednisolone (15\u2009mg per day) was then initiated, and the symptoms disappeared within a few days. This case illustrates the possibility that successful treatment of Cushing\u2019s syndrome may trigger emergence of a glucocorticoid-responsive disease.<\/jats:p>","DOI":"10.1136\/bcr-2019-232959","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T15:20:46Z","timestamp":1585668046000},"page":"e232959","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Remitting seronegative symmetrical synovitis with pitting oedema after surgical remission of Cushing\u2019s syndrome"],"prefix":"10.1136","volume":"13","author":[{"given":"Hiroaki","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Toshiba Rinkan Hospital, Sagamihara, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Urology, Toshiba Rinkan Hospital, Sagamihara, Kanagawa, 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