{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:02Z","timestamp":1756307402987,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,1,5]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Renal light chain deposit disease is a rare disease with rapid progression to renal failure when left untreated. There is no standard treatment available. We present a unique case of renal IgA kappa deposit disease who developed severe decline in renal function within a few months of diagnosis. She was started on a single regimen of cyclophosphamide, bortezomib and dexamethasone (CyBorD) followed by maintenance treatment with bortezomib and dexamethasone leading to rapid improvement of renal function. This is the first case to be reported on renal IgA kappa deposit disease who have responded dramatically to CyBorD without the need for any modification of the regimen or stem cell transplant.<\/jats:p>","DOI":"10.1136\/bcr-2019-232985","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T04:36:29Z","timestamp":1579149389000},"page":"e232985","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cyclophosphamide, bortezomib and dexamethasone (CyBorD): a promising regimen for renal light chain deposit disease"],"prefix":"10.1136","volume":"13","author":[{"given":"Arunima","family":"Dutta","sequence":"first","affiliation":[{"name":"Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Kesari","sequence":"additional","affiliation":[{"name":"Internal Medicine, McLaren Regional Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Singh","sequence":"additional","affiliation":[{"name":"Karmanos Cancer Institute, McLaren Regional Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"2025082707350575000_13.1.e232985.1","first-page":"1","article-title":"Treatment of light chain deposition disease using Bortezomib-Based regimen followed by Thalidomide-Based regimen in a Saudi male","volume":"2016","author":"Adamu","year":"2016","journal-title":"Case Rep Nephrol"},{"key":"2025082707350575000_13.1.e232985.2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.9.1939"},{"key":"2025082707350575000_13.1.e232985.3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00970207"},{"key":"2025082707350575000_13.1.e232985.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-390930"},{"key":"2025082707350575000_13.1.e232985.5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03160316"},{"key":"2025082707350575000_13.1.e232985.6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-495929"},{"key":"2025082707350575000_13.1.e232985.7","doi-asserted-by":"crossref","DOI":"10.4081\/cp.2011.e95","article-title":"Long-term reversibility of renal dysfunction associated to light chain deposition disease with bortezomib and dexamethasone and high dose therapy and autologous stem cell transplantation","volume":"1","author":"Gonz\u00e1lez-L\u00f3pez","year":"2011","journal-title":"Clin Pract"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-232985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:35:14Z","timestamp":1756305314000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-232985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,15]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/bcr-2019-232985"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-232985","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}