{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:40:04Z","timestamp":1756287604682,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,1,8]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Follicular lymphoma is the second most common subtype of non-Hodgkin's lymphoma affecting adults. Clinically, follicular lymphoma is generally indolent, most often presenting as a painless peripheral lymphadenopathy; however, a leucocytosis at presentation is exceedingly rare. We present the case of a 63-year-old woman with follicular lymphoma with a presenting hyperleucocytosis at diagnosis of 1\u2009327\u2009000\/\u03bcL demonstrated on laboratory analysis work while hospitalised for progressive weakness. fluorescence in situ hybridization (FISH) panel was consistent with follicular lymphoma, which was positive for B-cell leukaemia\/lymphoma 2 and negative for MYC Proto-Oncogene. Cytoreduction with rituximab-containing therapy was initiated, with the patient ultimately expiring. A leukaemic phase at presentation appears to be associated with poor outcome. The findings from our case, in addition to others, have potential implications in regard to prognostic utility. The current prognostic tool used to estimate overall survival for follicular lymphoma, Follicular Lymphoma International Prognostic Index, does not take leucocytosis into account.<\/jats:p>","DOI":"10.1136\/bcr-2019-233007","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:11:30Z","timestamp":1678752690000},"page":"e233007","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Follicular lymphoma presenting as hyperleucocytosis"],"prefix":"10.1136","volume":"13","author":[{"given":"Heidi A","family":"Worth","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Tennessee Knoxville, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Tennessee Knoxville, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Aljadir","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Tennessee Knoxville, Knoxville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"2025082702265689000_13.1.e233007.1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00277-006-0232-z","article-title":"Hyperleukocytosis in patients with leukemic follicular lymphoma","volume":"86","author":"Inaba","year":"2007","journal-title":"Ann Hematol"},{"doi-asserted-by":"publisher","key":"2025082702265689000_13.1.e233007.2","DOI":"10.3109\/10428194.2011.574753"},{"doi-asserted-by":"publisher","key":"2025082702265689000_13.1.e233007.3","DOI":"10.1136\/jcp.41.9.951"},{"key":"2025082702265689000_13.1.e233007.4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.leukres.2013.05.016","article-title":"Follicular lymphoma with leukemic phase at diagnosis: a series of seven cases and review of the literature","volume":"37","author":"Beltran","year":"2013","journal-title":"Leuk Res"},{"doi-asserted-by":"publisher","key":"2025082702265689000_13.1.e233007.5","DOI":"10.1111\/bjh.12675"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-233007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:27:02Z","timestamp":1756286822000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-233007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/bcr-2019-233007"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-233007","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}