{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:19:13Z","timestamp":1789258753756,"version":"build-2803163510"},"reference-count":20,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,4,21]]},"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Critically ill patients are at risk of developing both acute kidney injury (AKI) and invasive fungal infections (IFIs). Prompt and efficient treatment of the IFI is essential for the survival of the patient. This article examines three distinct clinical situations where liposomal amphotericin B, a broad-spectrum antifungal agent, was successfully used in the setting of AKI. The first was <jats:italic>Aspergillus<\/jats:italic> infection in a 63-year-old man with bleeding oesophageal varices related to advanced liver disease. The second was gastrointestinal mucormycosis in a 74-year-old man who developed a small bowel obstruction following an autologous stem cell transplant for mantle cell lymphoma. The third was a <jats:italic>Fusarium<\/jats:italic> infection in a 32-year-old woman on immunosuppression for a bilateral lung transplant for cystic fibrosis. In all three cases, liposomal amphotericin B was required for urgent management of the patient\u2019s IFI. We discuss the rationale for treatment with a potentially nephrotoxic agent in this setting.<\/jats:p>","DOI":"10.1136\/bcr-2019-233072","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T05:41:32Z","timestamp":1589348492000},"page":"e233072","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Optimal management of acute kidney injury in critically ill patients with invasive fungal infections being treated with liposomal amphotericin B"],"prefix":"10.1136","volume":"13","author":[{"given":"Darius","family":"Armstrong-James","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickey","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Haematology, St George's University Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Nephrology, Guy's and St Thomas' Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cockwell","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Queen Elizabeth Hospital Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"2025082800175111000_13.5.e233072.1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.1"},{"key":"2025082800175111000_13.5.e233072.2","unstructured":"Groth CM , Dodds-Ashley ES . 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