{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:17:53Z","timestamp":1792304273888,"version":"4.4.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,12,16]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7\u2009cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed the disease was limited to the vagina. The patient received six cycles of Rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone with significant improvement in her symptoms. Serial ultrasounds over the subsequent months showed appropriate development of the fetus. Whole body MRI after treatment showed decreased size and decreased signal of the primary pelvic mass compatible with favourable treatment response. Challenges in the management of this rare presentation of lymphoma are discussed.<\/jats:p>","DOI":"10.1136\/bcr-2019-233145","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:45:12Z","timestamp":1578030312000},"page":"e233145","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Diffuse large B-cell lymphoma of the vagina in pregnancy"],"prefix":"10.1136","volume":"13","author":[{"given":"Nwabundo","family":"Anusim","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olabisi","family":"Afolayan-Oloye","sequence":"additional","affiliation":[{"name":"Department of Anatomic and Clinical Pathology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna S","family":"Gaikazian","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"2025082723084622000_13.1.e233145.1","doi-asserted-by":"crossref","DOI":"10.4081\/hr.2018.7070","article-title":"Extranodal diffuse large B-cell lymphomas: a retrospective case series and review of the literature","volume":"10","author":"Boussios","year":"2018","journal-title":"Hematol Rep"},{"key":"2025082723084622000_13.1.e233145.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"2025082723084622000_13.1.e233145.3","article-title":"Primary vaginal non-Hodgkin lymphoma","volume":"10","author":"Contreras-Chavez","year":"2018","journal-title":"Cureus"},{"key":"2025082723084622000_13.1.e233145.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00747.x"},{"key":"2025082723084622000_13.1.e233145.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000178089.77018.a9"},{"key":"2025082723084622000_13.1.e233145.6","unstructured":"Key Statistics for Vaginal Cancer [Internet]. 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