{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:22:29Z","timestamp":1766514149279,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,4,13]]},"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>A 63-year-old woman was referred to neurology with bilateral severe progressive pain and stiffness in her thighs. The patient had a 3-year history of injecting intramuscular cyclizine into the anterior thigh to treat nausea associated with a longstanding pan-enteric dysmotility syndrome. MRI of the thighs demonstrated fibrotic appearances. A biopsy of the left vastus lateralis and surrounding fascia identified pathology consistent with a fibrous myopathy. The patient was advised to stop intramuscular injections of cyclizine and undergo physiotherapy but she still remained in considerable pain. Although fibrous myopathy occurring as a consequence of recurrent intramuscular drug injections, particularly heroin, has been previously described, this is the first report of fibrous myopathy associated with the use of intramuscular cyclizine. We highlight this rare association and suggest that the long-term use of intramuscular cyclizine be avoided.<\/jats:p>","DOI":"10.1136\/bcr-2019-233544","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T07:17:12Z","timestamp":1589267832000},"page":"e233544","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Fibrous myopathy induced by intramuscular injections of cyclizine"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-8844","authenticated-orcid":false,"given":"Rory James","family":"Tinker","sequence":"first","affiliation":[{"name":"Manchester Medical School, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Wiltshire","sequence":"additional","affiliation":[{"name":"Manchester Medical School, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"du Plessis","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Greater Manchester Neurosciences Centre, Salford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9230-4137","authenticated-orcid":false,"given":"James B","family":"Lilleker","sequence":"additional","affiliation":[{"name":"Centre for Musculoskeletal Research, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"2025082711270287000_13.5.e233544.1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000350185","article-title":"Neuronal mechanisms and the treatment of motion sickness","volume":"91","author":"Schm\u00e4l","year":"2013","journal-title":"Pharmacology"},{"key":"2025082711270287000_13.5.e233544.2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF03170501","article-title":"Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia","volume":"171","author":"Laffey","year":"2002","journal-title":"Ir J Med Sci"},{"key":"2025082711270287000_13.5.e233544.3","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1080\/21645515.2017.1334747","article-title":"Establishing a new appropriate intramuscular injection site in the deltoid muscle","volume":"13","author":"Nakajima","year":"2017","journal-title":"Hum Vaccin Immunother"},{"key":"2025082711270287000_13.5.e233544.4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jevs.2015.02.001","article-title":"Complications after intramuscular injections in Equids","volume":"35","author":"Puschmann","year":"2015","journal-title":"J Equine Vet Sci"},{"key":"2025082711270287000_13.5.e233544.5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1155\/2006\/198751","article-title":"Fibrous myopathy as a complication of repeated intramuscular injections for chronic headache","volume":"11","author":"Burnham","year":"2006","journal-title":"Pain Res Manag"},{"key":"2025082711270287000_13.5.e233544.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.168294"},{"key":"2025082711270287000_13.5.e233544.7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<274::AID-MUS21>3.0.CO;2-Y","article-title":"Focal myopathy induced by chronic heroin injection is reversible","volume":"23","author":"Weber","year":"2000","journal-title":"Muscle Nerve"},{"key":"2025082711270287000_13.5.e233544.8","unstructured":"Orphanet . 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