{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:17:11Z","timestamp":1769991431942,"version":"3.49.0"},"reference-count":21,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,4,16]]},"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50\u2009000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment with glucocorticoids and bisphosphonates was warranted during his second admission. The pathophysiology of hypercalcaemia from vitamin D intoxication results from the long-term effects of vitamin D storage in adipose tissue. In the present case, we discuss this pathophysiology and treatment approaches in the context of increasing awareness of and testing for vitamin D deficiency, and growing access to over-the-counter supplements.<\/jats:p>","DOI":"10.1136\/bcr-2019-233853","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T04:24:51Z","timestamp":1588220691000},"page":"e233853","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates"],"prefix":"10.1136","volume":"13","author":[{"given":"Chase C","family":"Houghton","sequence":"first","affiliation":[{"name":"Medicine, George Washington University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie Q","family":"Lew","sequence":"additional","affiliation":[{"name":"Medicine, George Washington University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"2025082800302429000_13.4.e233853.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2723"},{"key":"2025082800302429000_13.4.e233853.2","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1002\/jbmr.5650061413","article-title":"Differential diagnosis of hypercalcemia","volume":"6 Suppl 2","author":"Lafferty","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2025082800302429000_13.4.e233853.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0675"},{"key":"2025082800302429000_13.4.e233853.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"2025082800302429000_13.4.e233853.5","doi-asserted-by":"crossref","first-page":"582S","DOI":"10.1093\/ajcn\/88.2.582S","article-title":"Pharmacokinetics of vitamin D toxicity","volume":"88","author":"Jones","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2025082800302429000_13.4.e233853.6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058725","article-title":"Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial","volume":"8","author":"Hossein-nezhad","year":"2013","journal-title":"PLoS One"},{"key":"2025082800302429000_13.4.e233853.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042806"},{"key":"2025082800302429000_13.4.e233853.8","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613507530"},{"key":"2025082800302429000_13.4.e233853.9","doi-asserted-by":"publisher","DOI":"10.1530\/EC-16-0055"},{"key":"2025082800302429000_13.4.e233853.10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-4-200808190-00007"},{"key":"2025082800302429000_13.4.e233853.11","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553290"},{"key":"2025082800302429000_13.4.e233853.12","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-31-1-70"},{"key":"2025082800302429000_13.4.e233853.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.558"},{"key":"2025082800302429000_13.4.e233853.14","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328348b3cb"},{"key":"2025082800302429000_13.4.e233853.15","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.5.425"},{"key":"2025082800302429000_13.4.e233853.16","doi-asserted-by":"publisher","DOI":"10.1177\/1078155213518361"},{"key":"2025082800302429000_13.4.e233853.17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1001"},{"key":"2025082800302429000_13.4.e233853.18","unstructured":"Looker A , Johnson C , Lacher D , et al . Vitamin D status: United States, 2001\u20132006. Hyattsville, MD: National Center for Health Statistics, 2011."},{"key":"2025082800302429000_13.4.e233853.19","first-page":"1","article-title":"Vitamin D and calcium: a systematic review of health outcomes (update)","volume":"217","author":"Newberry","year":"2014","journal-title":"Evid Rep Technol Assess"},{"key":"2025082800302429000_13.4.e233853.20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.7326\/M14-1659","article-title":"Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force","volume":"162","author":"LeBlanc","year":"2015","journal-title":"Ann Intern Med"},{"key":"2025082800302429000_13.4.e233853.21","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2450"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-233853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:30:34Z","timestamp":1756366234000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-233853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,29]]},"published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1136\/bcr-2019-233853"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-233853","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}