{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:36:10Z","timestamp":1771576570363,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,3,13]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Peritoneal carcinomatosis (PC) is progression of the primary cancer to the peritoneum that is seen in only 1.2% of patients with lung cancer. It is associated with poor prognosis especially if present at the time of initial cancer diagnosis. The predisposing factors for peritoneal spread are not yet well understood. It has been suggested that the oncogene status of the tumour can influence the patterns of metastatic spread. There is not enough data about the role of c-ROS oncogene 1 (ROS1) mutation in the development of PC in non-small cell lung cancer. Here, we describe a case of a 56-year-old man who presented with new-onset ascites and was found to have PC. He was diagnosed with ROS1-rearranged lung adenocarcinoma. No obvious primary tumour was identified. Patient responded well to targeted therapy with crizotinib and remained 6 months free of disease progression.<\/jats:p>","DOI":"10.1136\/bcr-2019-233864","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T03:15:16Z","timestamp":1585192516000},"page":"e233864","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation"],"prefix":"10.1136","volume":"13","author":[{"given":"Vera","family":"Kazakova","sequence":"first","affiliation":[{"name":"Department of Medicine, St Elizabeth's Medical Center, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia V","family":"Alarcon Velasco","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, Dana Farber Cancer Institute at St Elizabeth's Medical Center, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr","family":"Perepletchikov","sequence":"additional","affiliation":[{"name":"Pathology, St Elizabeth's Medical Center, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S","family":"Lathan","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"2025082711374952000_13.3.e233864.1","unstructured":"Howlader N , Noone A , Krapcho M , et al . 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Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541114\/ [Accessed 29 Oct 2019]."},{"key":"2025082711374952000_13.3.e233864.9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.5114\/wo.2012.32495","article-title":"Relapse with isolated peritoneal metastasis in lung adenocarcinoma: and review of the literature","volume":"6","author":"Tanriverdi","year":"2012","journal-title":"Wsp\u00f3\u0142czesna Onkologia"},{"key":"2025082711374952000_13.3.e233864.10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3892\/ol.2013.1468","article-title":"Lung cancer and peritoneal carcinomatosis","volume":"6","author":"Sereno","year":"2013","journal-title":"Oncol Lett"},{"key":"2025082711374952000_13.3.e233864.11","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1111\/ajco.13131","article-title":"Clinical efficacy of concurrent bevacizumab for malignant ascites in nonsquamous cell carcinoma of the lung","volume":"15","author":"Hsu","year":"2019","journal-title":"Asia Pac J Clin Oncol"},{"key":"2025082711374952000_13.3.e233864.12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3892\/ol.2014.2169","article-title":"Rapid onset lung squamous cell carcinoma with prominent peritoneal carcinomatosis and an eosinophilic leukemoid reaction, with coexistence of the BRAF V600E and oncogenic KRAS G12A mutations: a case report","volume":"8","author":"Li","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082711374952000_13.3.e233864.13","doi-asserted-by":"crossref","unstructured":"Nassereddine H , Sannier A , Brosseau S , et al . Clinicopathological and molecular study of peritoneal carcinomatosis associated with non-small cell lung carcinoma. Pathol. Oncol. Res. 2019;136.doi:10.1007\/s12253-019-00713-1","DOI":"10.1007\/s12253-019-00713-1"},{"key":"2025082711374952000_13.3.e233864.14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1200\/JCO.2014.58.3302","article-title":"Crizotinib Therapy for Advanced Lung Adenocarcinoma and a ROS1 Rearrangement: Results From the EUROS1 Cohort","volume":"33","author":"Mazi\u00e8res","year":"2015","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"2025082711374952000_13.3.e233864.15","unstructured":"National Comprehensive Cancer Network . Non-Small Cell Lung Cancer (Version 7.2019) [Internet], 2019. Available: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/nscl.pdf [Accessed 26 Sep 2019]."},{"key":"2025082711374952000_13.3.e233864.16","doi-asserted-by":"crossref","unstructured":"Mazi\u00e8res J , Drilon A , Lusque A , et al . Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry. Ann Oncol Off J Eur Soc Med Oncol 2019.","DOI":"10.1093\/annonc\/mdz167"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-233864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:37:58Z","timestamp":1756319878000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-233864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,25]]},"published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1136\/bcr-2019-233864"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-233864","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}