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Urine antigen testing for <jats:italic>Histoplasma capsulatum<\/jats:italic> was negative, but a fungal complement fixation panel was reactive for <jats:italic>Histoplasma<\/jats:italic> antibodies. Skin biopsy revealed intracellular organisms consistent with <jats:italic>H. capsulatum<\/jats:italic>. She underwent treatment with liposomal amphotericin B but due to nephrotoxicity, drug interactions and worsening transaminitis, therapy was changed to itraconazole. The diagnosis and management of disseminated histoplasmosis presents multiple challenges, which are of particular importance in patients with a history of renal transplantation.<\/jats:p>","DOI":"10.1136\/bcr-2019-233976","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T05:57:10Z","timestamp":1591941430000},"page":"e233976","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-6596","authenticated-orcid":false,"given":"Surbhi","family":"Gupta","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-883X","authenticated-orcid":false,"given":"Colin Andrew","family":"Hinkamp","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Lo","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"2025082723034718000_13.6.e233976.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-824898"},{"key":"2025082723034718000_13.6.e233976.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.009"},{"key":"2025082723034718000_13.6.e233976.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00658.x"},{"key":"2025082723034718000_13.6.e233976.4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit593"},{"key":"2025082723034718000_13.6.e233976.5","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e3180679130"},{"key":"2025082723034718000_13.6.e233976.6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir435"},{"key":"2025082723034718000_13.6.e233976.7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMra1702693","article-title":"Post-Transplantation lymphoproliferative disorders in adults","volume":"378","author":"Dierickx","year":"2018","journal-title":"N Engl J Med"},{"key":"2025082723034718000_13.6.e233976.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2008-740ST"},{"key":"2025082723034718000_13.6.e233976.9","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12409"},{"key":"2025082723034718000_13.6.e233976.10","doi-asserted-by":"publisher","DOI":"10.1086\/604712"},{"key":"2025082723034718000_13.6.e233976.11","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"2025082723034718000_13.6.e233976.12","doi-asserted-by":"crossref","first-page":"E64","DOI":"10.1111\/tid.12059","article-title":"Cutaneous presentation of progressive disseminated histoplasmosis nine\u00a0years after renal transplantation","volume":"15","author":"Rosado-Odom","year":"2013","journal-title":"Transpl Infect Dis"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-233976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:03:54Z","timestamp":1756361034000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-233976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,11]]},"published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1136\/bcr-2019-233976"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-233976","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}