{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:05:15Z","timestamp":1780347915586,"version":"3.54.1"},"reference-count":6,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,4,13]]},"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Laboratory analysis did not show evidence of myositis. The patient was started on hydroxychloroquine for possible cutaneous lupus erythematosus. On follow-up, she presented with a new violaceous rash on the superior eyelids and a well-defined oval patch on the mid-hard palate suspicious for dermatomyositis. Myositis-specific autoantibodies revealed presence of anti-transcriptional intermediary factor-1\u03b3 (anti-TIF1\u03b3) in the serum. Anti-TIF1\u03b3 autoantibody-positive dermatomyositis is a newly recognised subtype of dermatomyositis that is highly associated with amyopathic disease and has an increased risk of malignancy, making prompt diagnosis crucial. This case highlights the utility of a thorough oral exam in patients suspected to have connective tissue disease as the distinctive ovoid palatal patch is nearly pathognomonic for anti-TIF1\u03b3 dermatomyositis.<\/jats:p>","DOI":"10.1136\/bcr-2019-234111","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T04:15:11Z","timestamp":1587701711000},"page":"e234111","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Ovoid palatal patch: a clue to anti-TIF1\u03b3 dermatomyositis"],"prefix":"10.1136","volume":"13","author":[{"given":"Ellen","family":"Franciosi","sequence":"first","affiliation":[{"name":"Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Houk","sequence":"additional","affiliation":[{"name":"Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Rashighi","sequence":"additional","affiliation":[{"name":"Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"},{"name":"Connective Tissue Disease Clinic and Research Center, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,4,23]]},"reference":[{"key":"2025082702455445000_13.4.e234111.1","doi-asserted-by":"crossref","DOI":"10.1097\/RHU.0000000000000874","article-title":"Ovoid palatal patch: an Ominous sign in dermatomyositis","author":"Bhattacharjee","year":"2018","journal-title":"J Clin Rheumatol"},{"key":"2025082702455445000_13.4.e234111.2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jamadermatol.2016.1429","article-title":"Ovoid palatal patch in dermatomyositis: a novel finding associated with Anti-TIF1\u03b3 (p155) antibodies","volume":"152","author":"Bernet","year":"2016","journal-title":"JAMA Dermatol"},{"key":"2025082702455445000_13.4.e234111.3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40257-016-0199-z","article-title":"Amyopathic dermatomyositis: a Concise review of clinical manifestations and associated malignancies","volume":"17","author":"Udkoff","year":"2016","journal-title":"Am J Clin Dermatol"},{"key":"2025082702455445000_13.4.e234111.4","first-page":"128","article-title":"The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum","volume":"31","author":"Ghazi","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"2025082702455445000_13.4.e234111.5","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jaad.2018.11.023","article-title":"Association of antinuclear antibody status with clinical features and malignancy risk in adult-onset dermatomyositis","volume":"80","author":"Hoesly","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2025082702455445000_13.4.e234111.6","first-page":"990","article-title":"Strong correlation between cancer progression and anti-transcription intermediary factor 1\u03b3 antibodies in dermatomyositis patients","volume":"36","author":"Ogawa-Momohara","year":"2018","journal-title":"Clin Exp Rheumatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-234111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:46:02Z","timestamp":1756287962000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-234111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,23]]},"published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1136\/bcr-2019-234111"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-234111","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}