{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:06Z","timestamp":1756339566563,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,6,8]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>A 56-year-old man with a remote history of bilateral recurrent facial palsies presented with a week of ophthalmoplegia with intact deep tendon reflexes and lack of ataxia, cerebrospinal fluid with albuminocytologic dissociation and elevated serum anti-ganglioside Q1b (GQ1b) IgG antibody. We diagnosed the patient with acute ophthalmoplegia without ataxia, a condition under the spectrum of anti-GQ1b antibody syndromes which also includes Miller Fisher syndrome. Given the rarity of recurrent facial palsies and anti-GQ1b antibody syndromes as well as reports associating facial palsies and this syndrome, we suggest that our case may be an unusual presentation of an anti-GQ1b antibody syndrome beginning with recurrent facial palsies several years prior to ophthalmoplegia. Prior studies of human nerves provide insight into the pathophysiology, including ganglioside distribution and cross-reactivities underlying the heterogeneity of anti-GQ1b antibody syndromes. This report may expand the differential diagnosis in patients with recurrent facial palsies and broaden the phenotype of anti-GQ1b syndromes.<\/jats:p>","DOI":"10.1136\/bcr-2020-234319","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T01:47:33Z","timestamp":1594345653000},"page":"e234319","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acute ophthalmoplegia in a patient with anti-GQ1b antibody and chronic facial diplegia"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0354-2871","authenticated-orcid":false,"given":"Fanny Huynh","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California San Diego Health System, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexan","family":"Yerevanian","sequence":"additional","affiliation":[{"name":"Department of 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