{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:24:16Z","timestamp":1790288656159,"version":"4.1.0"},"reference-count":14,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,5,21]]},"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Kidney tubular disorders due to monoclonal immunoglobulin light chains are common manifestations of B-cell neoplasm. Cast nephropathy (CN) is the most frequent type of these disorders and may present with acute kidney injury (AKI) due to the presence of excess light chains in the distal tubules. Light chain proximal tubulopathy (LCPT) is an uncommon form of renal disease and may present as Fanconi syndrome due to proximal tubular cell damage by intracellular deposition of light chains. The concomitant disorder of both CN and LCPT is rare given the inherent differences in the biochemical properties of the immunoglobulin light chains of each disorder. We report a 64-year-old man who presented with AKI and Fanconi syndrome who was discovered to have both CN and LCPT due to the underlying disorder of monoclonal gammopathy of renal significance and who has responded favourably with conventional chemotherapy. We also review the existing literature on this interesting subject.<\/jats:p>","DOI":"10.1136\/bcr-2020-234361","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T02:29:39Z","timestamp":1593397779000},"page":"e234361","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Light chain proximal tubulopathy with cast nephropathy in monoclonal gammopathy of renal significance"],"prefix":"10.1136","volume":"13","author":[{"given":"Rebaika","family":"Chopra","sequence":"first","affiliation":[{"name":"Medicine, James J Peters VA Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Santana de Roberts","sequence":"additional","affiliation":[{"name":"Medicine, Jacobi Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Batal","sequence":"additional","affiliation":[{"name":"Pathology, NewYork-Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Batra","sequence":"additional","affiliation":[{"name":"Medicine, James J Peters VA Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Jim","sequence":"additional","affiliation":[{"name":"Medicine, Jacobi Medical Center, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"2025082712565558000_13.6.e234361.1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020139"},{"key":"2025082712565558000_13.6.e234361.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90601-4"},{"key":"2025082712565558000_13.6.e234361.3","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200005000-00002"},{"key":"2025082712565558000_13.6.e234361.4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020185"},{"key":"2025082712565558000_13.6.e234361.5","doi-asserted-by":"crossref","DOI":"10.4103\/0971-4065.138700","article-title":"Light chain proximal tubulopathy with cast nephropathy in a case of multiple myeloma","volume":"25","author":"Gowda","year":"2015","journal-title":"Indian J Nephrol"},{"key":"2025082712565558000_13.6.e234361.6","doi-asserted-by":"crossref","unstructured":"Wu C-K , Yang A-H , Lai H-C , et al . 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