{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:22:51Z","timestamp":1779294171393,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,5,13]]},"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Neurofibromatosis type 1 (NF1, Von Recklinghausen disease) is an autosomal dominant disease with a birth incidence of 1\/2500\u20133000. The most common presentations of NF1 are cutaneous presentations like caf\u00e9-au-lait spots and neurofibromas. 5%\u201325% of patients with NF1 have gastrointestinal manifestations of the disease. Appendiceal neurofibroma are extremely rare and only a few cases are described in literature. An appendectomy is indicated because of high risk of appendicitis and malignant transformation. We report the case of a 74-year-old male patient with a history of NF1 with chronic right lower quadrant pain. Successive imaging scans showed suspicion of chronic appendicitis. A diagnostic laparoscopy, resulting in a laparoscopic appendectomy was performed without complications. Histopathology showed appendiceal neurofibroma and diverticula. The postoperative course was uneventful. In patients with NF1 with right lower quadrant pain benign appendiceal neurofibroma should be included in the differential diagnosis. A diagnostic laparoscopy should be performed followed by an appendectomy.<\/jats:p>","DOI":"10.1136\/bcr-2020-234383","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:59:32Z","timestamp":1591250372000},"page":"e234383","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Appendiceal neurofibroma and diverticula in a neurofibromatosis type 1 patient with chronic right lower quadrant pain"],"prefix":"10.1136","volume":"13","author":[{"given":"Katrien","family":"Van de Steen","sequence":"first","affiliation":[{"name":"Abdominal Surgery, Zuyderland Medical Centre, Heerlen, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Riedl","sequence":"additional","affiliation":[{"name":"Pathology, Zuyderland Medical Centre, Heerlen, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Strypstein","sequence":"additional","affiliation":[{"name":"Abdominal Surgery, University Hospitals Leuven, Leuven, Flanders, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert-Jan","family":"Boerma","sequence":"additional","affiliation":[{"name":"Abdominal Surgery, Zuyderland Medical Centre, Heerlen, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"2025082722510351000_13.6.e234383.1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.epsc.2015.09.011","article-title":"Surgical management of an appendiceal neurofibroma in a neurofibromatosis-1 patient: a case report","volume":"3","author":"Wilson","year":"2015","journal-title":"J Pediatr Surg Case Rep"},{"key":"2025082722510351000_13.6.e234383.2","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3892\/ol.2014.2498","article-title":"Giant appendiceal neurofibroma in von Recklinghausen's disease: a case report and literature review","volume":"8","author":"Guo","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082722510351000_13.6.e234383.3","first-page":"852","article-title":"Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen's disease): clinicopathological spectrum with pathogenetic considerations","volume":"5","author":"Agaimy","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"2025082722510351000_13.6.e234383.4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijscr.2018.11.005","article-title":"Appendiceal neurofibroma with low-grade appendiceal mucinous neoplasm in neurofibromatosis type 1 patient: a case report","volume":"53","author":"Komo","year":"2018","journal-title":"Int J Surg Case Rep"},{"key":"2025082722510351000_13.6.e234383.5","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310005712"},{"key":"2025082722510351000_13.6.e234383.6","first-page":"68","article-title":"A case of neurofibroma of the appendix in von Recklinghausen disease","volume":"108","author":"Sugimoto","year":"2011","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"2025082722510351000_13.6.e234383.7","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.3748\/wjg.v21.i33.9817","article-title":"Perforated appendiceal diverticulitis associated with appendiceal neurofibroma in neurofibromatosis type 1","volume":"21","author":"Ozaki","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2025082722510351000_13.6.e234383.8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/1319-3767.39623","article-title":"Intra-Abdominal manifestations of von Recklinghausen's neurofibromatosis","volume":"14","author":"Rastogi","year":"2008","journal-title":"Saudi J Gastroenterol"},{"key":"2025082722510351000_13.6.e234383.9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5114\/pjp.2016.62829","article-title":"The relationship between diverticula and low-grade mucinous neoplasm of the appendix. does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?","volume":"67","author":"Pasaoglu","year":"2016","journal-title":"Pol J Pathol"},{"key":"2025082722510351000_13.6.e234383.10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jscr\/rjz332","article-title":"Appendiceal diverticulitis presenting as acute appendicitis diagnosed postoperatively","volume":"2019","author":"Albeeshi","year":"2019","journal-title":"J Surg Case Rep"},{"key":"2025082722510351000_13.6.e234383.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.001"},{"key":"2025082722510351000_13.6.e234383.12","first-page":"3","article-title":"Appendix Diverticula - 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