{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:35:25Z","timestamp":1785854125254,"version":"3.56.0"},"reference-count":29,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,5,7]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Biktarvy (bictegravir\/emtricitabine\/tenofovir alafemanide), which has been recently approved for the treatment of HIV, is a single-pill regimen that associates bictegravir and a novel integrase strand transfer inhibitor (INSTI) with a combination of two nucleoside reverse transcriptase inhibitors (NRTI) of emtricitabine and tenofovir alafemanide. Among treatment complications, rhabdomyolysis has been reported in association with some NRTI and INSTI but never with bictegravir. Acute pancreatitis has also been reported recently with another INSTI, dolutegravir. We report here a 62-year-old man with diabetes and HIV infection, and receiving Biktarvy for 1\u2009month. He presented to the emergency department for muscular pain and fatigue. He was on treatment with Descovy (tenofovir alafenamide\/emtricitabine) and Viramune (nevirapine) for 2\u2009years but he recently asked for a regimen simplification. Severe rhabdomyolysis and acute pancreatitis were diagnosed. Although the aetiology of these events could be multifactorial, it cannot be ruled out that this episode could be linked to a potential side effect of bictegravir.<\/jats:p>","DOI":"10.1136\/bcr-2020-234483","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T02:25:29Z","timestamp":1593656729000},"page":"e234483","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Severe rhabdomyolysis and acute asymptomatic pancreatitis following the concomitant use of Biktarvy in the setting of hyperosmolar diabetic crisis"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-566X","authenticated-orcid":false,"given":"Sylvain Raoul","family":"Simeni Njonnou","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne, Facult\u00e9 de M\u00e9decine et des Sciences Pharmaceutiques, Universit\u00e9 de Dschang, Dschang, Cameroon"},{"name":"Department of Internal Medicine, HIV Reference Center, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Henrard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, HIV Reference Center, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"},{"name":"Department of Endocrinology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamya","family":"Noure","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, HIV Reference Center, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"},{"name":"Department of Endocrinology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Goffard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, HIV Reference Center, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"},{"name":"Department of Endocrinology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Hopital Erasme, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2025082703204558000_13.7.e234483.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2016"},{"key":"2025082703204558000_13.7.e234483.2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mus.24606","article-title":"Diagnostic evaluation of rhabdomyolysis","volume":"51","author":"Nance","year":"2015","journal-title":"Muscle Nerve"},{"key":"2025082703204558000_13.7.e234483.3","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32830e2774"},{"key":"2025082703204558000_13.7.e234483.4","first-page":"646","article-title":"Anti-retrovirals and immunosuppressive drug interactions in a HIV-positive patient after liver transplantation","volume":"51","author":"Antonini","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"2025082703204558000_13.7.e234483.5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.9.1692"},{"key":"2025082703204558000_13.7.e234483.6","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.eimc.2014.02.020","article-title":"Severe or life-threatening interactions between antiretrovirals and non-HIV drugs","volume":"33","author":"Manzardo","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2025082703204558000_13.7.e234483.7","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-015-0465-0"},{"key":"2025082703204558000_13.7.e234483.8","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20338"},{"key":"2025082703204558000_13.7.e234483.9","unstructured":"European AIDS Clinical Society, EACS . EACS guidelines version 10.0. Brussels: Belgium, 2019. Available: www.eacsociety.org\/guidelines\/eacs-guidelines\/eacs-guidelines.html"},{"key":"2025082703204558000_13.7.e234483.10","unstructured":"VIDAL - BIKTARVY (bict\u00e9gravir, emtricitabine, t\u00e9nofovir alaf\u00e9namide)\u202f: nouvelle trith\u00e9rapie contre l\u2019infection par le VIH-1 - Actualit\u00e9s. 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