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The ability of mesenchymal stem cells (MSCs) to differentiate along a mesodermal cell lineage, including tenocytes, and secrete various bioactive regenerative and anti-inflammatory molecules has seen them considered as a future reparative therapy for tendinopathy. Preclinical trials with MSCs have shown promising positive functional and structural outcomes in several connective tissue related conditions. A 52-year-old male professional masters golfer presents with a clinical history of common extensor origin tendinopathy of the elbow. Subsequent formal ultrasound showed evidence of a large intrasubstance tear. The patient underwent intratendinous autologous adipose-derived MSC therapy in combination with autologous platelet-rich plasma. Following treatment, the patient reported progressive improvement as measured by the validated Numeric Pain Rating Scale and Patient-Rated Tennis Elbow Evaluation score. Repeat imaging showed successful regeneration of tendon-like tissue.<\/jats:p>","DOI":"10.1136\/bcr-2020-234592","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T19:08:10Z","timestamp":1593544090000},"page":"e234592","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of autologous adipose-derived mesenchymal stem cell therapy in combination with autologous platelet-rich plasma in the treatment of elbow tendinopathy"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-4368","authenticated-orcid":false,"given":"Julien","family":"Freitag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Wickham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abi","family":"Tenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"2020063011022196000_13.6.e234592.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5919(03)00004-8"},{"key":"2020063011022196000_13.6.e234592.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61308-6"},{"key":"2020063011022196000_13.6.e234592.3","first-page":"245","article-title":"Zur genese und behandlung des schreibekrampfes","volume":"10","author":"Runge","year":"1873","journal-title":"Berl Klin Wochenschr"},{"key":"2020063011022196000_13.6.e234592.4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0278-5919(20)30489-0","article-title":"Elbow tendinosis\/tennis elbow","volume":"11","author":"Nirschl","year":"1992","journal-title":"Clin Sports Med"},{"key":"2020063011022196000_13.6.e234592.5","first-page":"263","article-title":"Tennis elbow. anatomical, epidemiological and therapeutic aspects","volume":"18","author":"Verhaar","year":"1994","journal-title":"Int Orthop"},{"key":"2020063011022196000_13.6.e234592.6","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199903000-00010"},{"key":"2020063011022196000_13.6.e234592.7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B2.9154"},{"key":"2020063011022196000_13.6.e234592.8","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091957"},{"key":"2020063011022196000_13.6.e234592.9","first-page":"163","article-title":"Stem cell technology for tendon regeneration: current status, challenges, and future research directions","volume":"8","author":"Lui","year":"2015","journal-title":"Stem Cells Cloning"},{"key":"2020063011022196000_13.6.e234592.10","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100160403"},{"key":"2020063011022196000_13.6.e234592.11","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01396"},{"key":"2020063011022196000_13.6.e234592.12","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096794"},{"key":"2020063011022196000_13.6.e234592.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1607-9"},{"key":"2020063011022196000_13.6.e234592.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-014-2391-1"},{"key":"2020063011022196000_13.6.e234592.15"},{"key":"2020063011022196000_13.6.e234592.16","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1002\/stem.2110","article-title":"Treatment of lateral epicondylosis by using allogeneic adipose-derived mesenchymal stem cells: a pilot study","volume":"33","author":"Lee","year":"2015","journal-title":"Stem Cells"},{"key":"2020063011022196000_13.6.e234592.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.05.005"},{"key":"2020063011022196000_13.6.e234592.18","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0217"},{"key":"2020063011022196000_13.6.e234592.19","doi-asserted-by":"crossref","unstructured":"Freitag J , Shah K , Wickham J , et al . 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