{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T15:03:32Z","timestamp":1763910212896,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,3]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>We report a case of a 53-year-old woman who presented initially with sepsis and later in her stay developed a severe and rapidly progressing hyperthermia after a decrease in oral baclofen dosage. Her fever peaked at 42.5<jats:sup>\u25cb<\/jats:sup>C (108.5<jats:sup>\u25cb<\/jats:sup>F), creating a broad differential diagnosis and complicating her initial sepsis diagnosis. When the oral baclofen dose was increased, the fevers resolved which confirmed the clinical diagnosis of baclofen withdrawal. Dose reductions of oral baclofen should be made gradually and with caution, and patients should be monitored for fevers as a possible symptom of baclofen withdrawal.<\/jats:p>","DOI":"10.1136\/bcr-2020-234710","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T17:37:12Z","timestamp":1601401032000},"page":"e234710","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Severe hyperthermia due to oral baclofen withdrawal"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-4212","authenticated-orcid":false,"given":"Vishesh","family":"Paul","sequence":"first","affiliation":[{"name":"Pulmonary & Critical Care Medicine, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Righter","sequence":"additional","affiliation":[{"name":"Pharmacology, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Kim","sequence":"additional","affiliation":[{"name":"Pharmacology, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weston","family":"Nadherny","sequence":"additional","affiliation":[{"name":"Internal Medicine, Carle Foundation Hospital, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"2025082723182681000_13.9.e234710.1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s13311-011-0025-5","article-title":"Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury","volume":"8","author":"Rabchevsky","year":"2011","journal-title":"Neurotherapeutics"},{"key":"2025082723182681000_13.9.e234710.2","first-page":"117","article-title":"Effects of baclofen on motor units paralysed by chronic cervical spinal cord injury","volume":"133","author":"Thomas","year":"2010","journal-title":"Brain (Stetkarova I, Brabec K, Vasko P, Mencl L. 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