{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:30:39Z","timestamp":1790231439633,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,5]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>We present the first young paediatric patient with desmoplastic small round cell tumour (DSRCT) treated in UK with hyperthermic intraperitoneal chemotherapy (HIPEC). A 7-year-old girl was diagnosed with abdominal DSRCT with peritoneal and liver metastases. After six cycles of chemotherapy she obtained a partial response, including almost complete resolution of the two liver metastases. It was decided to pursue cytoreductive surgery (CRS) combined with HIPEC, a procedure commonly performed in adults, but seldom in a child. The surgery was macroscopically complete and the HIPEC uncomplicated. She continued treatment without delays, including whole abdomino-pelvic radiotherapy and maintenance chemotherapy (cyclophosphamide\/vinorelbine for 12 months). She is currently in complete remission 4\u2009months after end of treatment and 26 months after diagnosis. HIPEC was made possible by successful collaboration between multiple teams. CRS-HIPEC proved to be safe and feasible and could be offered to other children with diagnoses of peritoneal malignancies across the UK.<\/jats:p>","DOI":"10.1136\/bcr-2020-234876","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T12:49:01Z","timestamp":1611838141000},"page":"e234876","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-9044","authenticated-orcid":false,"given":"Tomas","family":"Sjoberg Bexelius","sequence":"first","affiliation":[{"name":"Paediatrics, St George's University Hospitals NHS Foundation Trust, London, UK"},{"name":"Women's and Children's Health, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Paediatric Haemato-oncology, Royal Marsden Hospital NHS Trust, London, UK"},{"name":"Unit for Sarcoma Clinical Trials in Children, ICR, Sutton, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Okoye","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, St George's University Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Cecil","sequence":"additional","affiliation":[{"name":"Basingstoke and North Hampshire Hospital, Peritoneal Malignancy Institute Basingstoke, Hampshire Partnership NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Angelini","sequence":"additional","affiliation":[{"name":"Paediatric Haemato-oncology, Royal Marsden Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Dayal","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute, Hampshire Hospital, Basingstoke, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"2025082803451382000_14.1.e234876.1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0022-3468(93)90508-I","article-title":"The desmoplastic round cell tumor: a new solid tumor of childhood","volume":"28","author":"Crombleholme","year":"1993","journal-title":"J Pediatr Surg"},{"key":"2025082803451382000_14.1.e234876.2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-3-14"},{"key":"2025082803451382000_14.1.e234876.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-309"},{"key":"2025082803451382000_14.1.e234876.4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4081\/rt.2016.6145","article-title":"Clinical characteristics and outcomes of pediatric patients with desmoplastic small round cell tumor","volume":"8","author":"Bent","year":"2016","journal-title":"Rare Tumors"},{"key":"2025082803451382000_14.1.e234876.5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.suronc.2019.04.002","article-title":"Can we cure patients with abdominal desmoplastic small round cell tumor? results of a retrospective multicentric study on 100 patients","volume":"29","author":"Honor\u00e9","year":"2019","journal-title":"Surg Oncol"},{"key":"2025082803451382000_14.1.e234876.6","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0408"},{"key":"2025082803451382000_14.1.e234876.7","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-4-3"},{"key":"2025082803451382000_14.1.e234876.8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/cam4.1940","article-title":"Desmoplastic small round cell tumors: multimodality treatment and new risk factors","volume":"8","author":"Scheer","year":"2019","journal-title":"Cancer Med"},{"key":"2025082803451382000_14.1.e234876.9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1245\/s10434-018-6333-9","article-title":"Desmoplastic small round cell tumor treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: results of a phase 2 trial","volume":"25","author":"Hayes-Jordan","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"2025082803451382000_14.1.e234876.10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3269-y"},{"key":"2025082803451382000_14.1.e234876.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171639","article-title":"Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: is there a benefit for HIPEC after macroscopically complete cytoreductive surgery?","volume":"12","author":"Honor\u00e9","year":"2017","journal-title":"PLoS One"},{"key":"2025082803451382000_14.1.e234876.12","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26934","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: a French nationwide study over 14 years","volume":"65","author":"Scalabre","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"2025082803451382000_14.1.e234876.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5703"},{"key":"2025082803451382000_14.1.e234876.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"2025082803451382000_14.1.e234876.15","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.36.18_suppl.LBA3503","article-title":"A UNICANCER phase III trial of hyperthermic intra-peritoneal chemotherapy (HIPEC) for colorectal peritoneal carcinomatosis (PC): PRODIGE 7","volume":"36","author":"Quenet","year":"2018","journal-title":"JCO"},{"key":"2025082803451382000_14.1.e234876.16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1245\/s10434-019-07339-2","article-title":"Desmoplastic small round cell tumor: long-term complications after cytoreduction and hyperthermic intraperitoneal chemotherapy","volume":"27","author":"Stiles","year":"2020","journal-title":"Ann Surg Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2020-234876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:45:28Z","timestamp":1756377928000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2020-234876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/bcr-2020-234876"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2020-234876","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}