{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:31:28Z","timestamp":1774895488579,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,8,6]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Endometrial large-cell neuroendocrine carcinoma admixed with a high-grade serous (HGS) adenocarcinoma is extremely rare with only one reported case in the literature. We present the second reported case in a 47-year-old woman who presented with abdominal pain, distension and loss of weight. On examination she had a fixed pelvic mass and vascular left vaginal mass. Imaging confirmed a 13\u2009cm solid cystic rectouterine pelvic mass, omental disease and retroperitoneal lymphadenopathy. She underwent a modified posterior exenteration, partial posterior vaginectomy, omentectomy and Hartmanns procedure with suboptimal debulking. Histopathology revealed a stage 4B mixed carcinoma with large cell neuroendocrine (70%) and HGS carcinoma (30%). Eight cycles of adjuvant cisplatin and paclitaxel were given with a complete radiological and biochemical response after 7 months. Unfortunately, she developed widespread recurrence at 9 month and was offered second line chemotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2020-234977","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T02:35:21Z","timestamp":1599100521000},"page":"e234977","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium"],"prefix":"10.1136","volume":"13","author":[{"given":"Liesel Elisabeth","family":"Hardy","sequence":"first","affiliation":[{"name":"Gynaecology Oncology, King Edward Memorial Hospital for Women Perth, Subiaco, Western Australia, Australia"},{"name":"Anatomical Pathology, PathWest Laboratory Medical WA, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia","family":"Chaudry","sequence":"additional","affiliation":[{"name":"Anatomical 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