{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:22:33Z","timestamp":1785352953463,"version":"3.55.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,12,10]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>A 34-year-old patient had her first trimester Down syndrome scan followed by serial ultrasound scans which showed a single intrauterine pregnancy with multiple cystic areas in the anterior placenta. She presented in preterm labour with a breech presentation at 32 weeks and underwent an emergency caesarean section. She delivered a male infant weighing 1750 g. The placental histopathology showed a complete hyatidiform mole. At 4 weeks postpartum, beta-human chorionic gonadotrophin (Bhcg) levels rose from 460 to 836 mIU\/mL over 1\u2009week. Metastatic workup revealed prominent pelvic nodes and pulmonary nodules in both lungs. This was discussed at the Multi-Disciplinary Tumour Board and single-agent intramuscular methotrexate was recommended. After chemotherapy, she achieved Bhcg normalisation after three cycles. This case highlights the importance of clinical vigilance even in low-risk patients. Unexpected findings on ultrasound should involve multidisciplinary input with radiology colleagues. A high index of suspicion for gestational trophoblastic disease and close follow-up is imperative.<\/jats:p>","DOI":"10.1136\/bcr-2020-235028","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T11:52:04Z","timestamp":1610970724000},"page":"e235028","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Management of a complete hydatidiform mole with a coexisting live fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease: learning points"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-8411","authenticated-orcid":false,"given":"Zhun Wei","family":"Mok","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurshid","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee Lin","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2025082723592176000_14.1.e235028.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2941501","article-title":"Delivery of euthyroid baby following hyperthyroidism in twin gestation with coexisting complete hydatidiform mole","volume":"2019","author":"Raj","year":"2019","journal-title":"Case Rep Endocrinol"},{"key":"2025082723592176000_14.1.e235028.2","doi-asserted-by":"crossref","first-page":"100519","DOI":"10.1016\/j.gore.2019.100519","article-title":"A challenging case of twin pregnancy with complete hydatidiform mole and co-existing normal live fetus - A case report and review of the literature","volume":"31","author":"Lipi","year":"2020","journal-title":"Gynecol Oncol Rep"},{"key":"2025082723592176000_14.1.e235028.3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejogrb.2015.05.017","article-title":"Individualistic approach to the management of complete hydatidiform mole with coexisting live fetus","volume":"191","author":"Rohilla","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2025082723592176000_14.1.e235028.4","unstructured":"The Royal College of Obstetricians and Gynaecologists . 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