{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:40:03Z","timestamp":1756366803884,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,7,7]]},"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>A young man with a history of early-onset coronary disease presented with an ST-elevation myocardial infarction at the age of 38. He subsequently had recurrent in-stent restenosis requiring repeating interventions and ultimately bypass surgery. After 4 years, he presents with systemic symptoms, new skin lesions and a femoral artery pseudoaneurysm. He is diagnosed with Beh\u00e7et syndrome, a rare systemic vasculitis characterised by the triad of oral aphthous ulcers, genital ulcers and ocular involvement. Beh\u00e7et is not associated with premature coronary disease but can have a variety of cardiac complications. Additionally, pathergy, an exaggerated inflammatory response to local injury, is characteristic. We hypothesise that in retrospect, subclinical inflammation and a vascular pathergy likely predisposed him to his cardiac and vascular complications. Here, we review risk factors and presentation of premature coronary artery disease and review the literature on the cardiovascular complications of Beh\u00e7et syndrome.<\/jats:p>","DOI":"10.1136\/bcr-2020-235039","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T03:20:28Z","timestamp":1598325628000},"page":"e235039","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Premature coronary disease, in-stent restenosis and vascular complications in a young man with Beh\u00e7et syndrome"],"prefix":"10.1136","volume":"13","author":[{"given":"Nathan R","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of California San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satvik","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, University of California San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerem","family":"Yeghiazarians","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, University of California San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"2025082800015979000_13.8.e235039.1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/clc.4960190809","article-title":"Myocardial infarction in men aged 40 years or less: a prospective clinical-angiographic study","volume":"19","author":"Fournier","year":"1996","journal-title":"Clin Cardiol"},{"key":"2025082800015979000_13.8.e235039.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.4.712"},{"key":"2025082800015979000_13.8.e235039.3","unstructured":"Doughty M , Mehta R , Bruckman D , et al . 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Coronary involvement in patients with Beh\u00e7et\u2019s disease. 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