{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:05:08Z","timestamp":1792188308101,"version":"4.4.0"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,9,16]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Hypothalamo-pituitary sarcoidosis is a rare manifestation of sarcoidosis, usually presenting alongside other symptoms of neurosarcoidosis. We describe the case of a 58-year-old man from Ghana who presented with progressive gait disturbance, cognitive dysfunction, hypothermia and bradycardia. He was found to have pituitary stalk thickening on imaging, and lymph node biopsy identified non-caseating granulomatous disease. Serology revealed gonadotropin deficiency, hypothyroidism and central adrenal insufficiency. Treatment with immunomodulatory therapy resulted in resolution of findings on imaging and improved cognition, though pituitary function never recovered. Treatment for his sarcoidosis unfortunately resulted in recurrent infections and avascular necrosis. Work-up, management and ongoing care required multidisciplinary cooperation between the admitting internal medicine team, infectious diseases, respirology, rheumatology, endocrinology and neurology.<\/jats:p>","DOI":"10.1136\/bcr-2020-235077","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T17:15:14Z","timestamp":1601831714000},"page":"e235077","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Neurosarcoidosis presenting with hypopituitarism"],"prefix":"10.1136","volume":"13","author":[{"given":"Elina","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rohr","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"AlMehthel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"2025082803142034000_13.10.e235077.1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1001\/jamaneurol.2018.2295","article-title":"Definition and consensus diagnostic criteria for neurosarcoidosis: from the neurosarcoidosis Consortium consensus group","volume":"75","author":"Stern","year":"2018","journal-title":"JAMA Neurol"},{"key":"2025082803142034000_13.10.e235077.2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0037-1604165","article-title":"Neurosarcoidosis","volume":"38","author":"Culver","year":"2017","journal-title":"Semin Respir Crit Care 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