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In this case report, we discuss the presentation and management of a 39-year-old grand multiparous lady with MELAS syndrome, which was diagnosed prior to her eighth pregnancy, discuss potential implications of the condition in pregnancy and summarise the current guidelines for the management of this rare condition.<\/jats:p>","DOI":"10.1136\/bcr-2020-235111","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T12:58:26Z","timestamp":1617800306000},"page":"e235111","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome in pregnancy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-5743","authenticated-orcid":false,"given":"Deepa","family":"Balachandran Nair","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Stoke Mandeville Hospital, Aylesbury, UK"},{"name":"Department of Obstetrics and Gynaecology, University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeswari","family":"Parasuraman","sequence":"additional","affiliation":[{"name":"Wessex Fetal Medicine Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Howe","sequence":"additional","affiliation":[{"name":"Wessex Fetal Medicine Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2025082802465891000_14.4.e235111.1","unstructured":"Newcastle-mitochondria.com . 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