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Further evaluation revealed acute Epstein-Barr virus (EBV) infection and hereditary spherocytosis. Her condition improved after 4 days on piperacillin\/tazobactam, intravenous fluids, analgesics and antipyretics. Our case report describes a thorough clinical evaluation of a patient with fever, anaemia, massive splenomegaly and multiple splenic infarcts. It highlights the need for careful interpretation of multiple positive IgM results on viral serological testing that often accompanies acute EBV infections.<\/jats:p>","DOI":"10.1136\/bcr-2020-235131","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:32:59Z","timestamp":1594708379000},"page":"e235131","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Multiple splenic infarcts: unusual presentation of hereditary spherocytosis associated with acute Epstein-Barr virus infection"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-4682","authenticated-orcid":false,"given":"Aye Mon","family":"Thida","sequence":"first","affiliation":[{"name":"Department of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifeanyi","family":"Ilonzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Woodhull Medical and Mental Health Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouyan","family":"Gohari","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Department, Woodhull Medical and Mental Health Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"2025082713114975000_13.7.e235131.1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12546"},{"key":"2025082713114975000_13.7.e235131.2","unstructured":"Hereditary spherocytosis . 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